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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 02, 2018 |
| Title |
A de novo mouse model of C11orf95-RELA fusion-driven ependymoma identifies driver functions in addition to NFκB |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The vast majority of supratentorial ependymomas (ST-EPNs) have few mutations other than chromosomal rearrangements on chromosome 11, most generating a fusion between C11orf95 and RELA (CR). This CR fusion can transform stem cells ex vivo rendering them oncogenic and may possess NF-κB activity, which has been proposed to be a mechanism of oncogenesis. However, it is not known whether CR is sufficient for EPN formation in vivo, and from what cell type and location. We found that CR is sufficient to form tumors from cells in the ependymal zone in mice that show many molecular and histologic similarities to human ST-EPN. Furthermore, the activation of NF-κB by this fusion protein appears minimal and not related to its oncogenic activity
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| Overall design |
C11orf95-RELA is a potent oncogene for supratentorial ependymoma
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| Contributor(s) |
Ozawa T, Arora S, Szulzewsky F, Juric-Sekhar G, Miyajima Y, Bolouri H, Yasui Y, Barber J, Dalton J, Jones TS, Nakada M, Kumabe T, Ellison DW, Gilbertson RJ, Holland EC |
| Citation(s) |
29949764 |
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| Submission date |
Jan 18, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Sonali Arora |
| E-mail(s) |
sarora@fredhutch.org
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| Organization name |
FHCRC
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| Street address |
1100 Fairview Ave N,
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| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (38)
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| Relations |
| BioProject |
PRJNA362328 |
| SRA |
SRP096964 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE93765_RAW.tar |
3.2 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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