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Series GSE93765 Query DataSets for GSE93765
Status Public on May 02, 2018
Title A de novo mouse model of C11orf95-RELA fusion-driven ependymoma identifies driver functions in addition to NFκB
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The vast majority of supratentorial ependymomas (ST-EPNs) have few mutations other than chromosomal rearrangements on chromosome 11, most generating a fusion between C11orf95 and RELA (CR). This CR fusion can transform stem cells ex vivo rendering them oncogenic and may possess NF-κB activity, which has been proposed to be a mechanism of oncogenesis. However, it is not known whether CR is sufficient for EPN formation in vivo, and from what cell type and location. We found that CR is sufficient to form tumors from cells in the ependymal zone in mice that show many molecular and histologic similarities to human ST-EPN. Furthermore, the activation of NF-κB by this fusion protein appears minimal and not related to its oncogenic activity
Overall design C11orf95-RELA is a potent oncogene for supratentorial ependymoma
Contributor(s) Ozawa T, Arora S, Szulzewsky F, Juric-Sekhar G, Miyajima Y, Bolouri H, Yasui Y, Barber J, Dalton J, Jones TS, Nakada M, Kumabe T, Ellison DW, Gilbertson RJ, Holland EC
Citation(s) 29949764
Submission date Jan 18, 2017
Last update date May 15, 2019
Contact name Sonali Arora
Organization name FHCRC
Street address 1100 Fairview Ave N,
City Seattle
State/province WA
ZIP/Postal code 98109
Country USA
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (38)
GSM2461747 Rela replicate 1
GSM2461748 Rela replicate 2
GSM2461749 RELA-S536E replicate 1
BioProject PRJNA362328
SRA SRP096964

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93765_RAW.tar 3.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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