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Series GSE94309 Query DataSets for GSE94309
Status Public on Nov 15, 2017
Title Control of plant cell fate transitions by transcriptional and hormonal signals [RNA-seq: mock_vs_dex_3h]
Organism Arabidopsis thaliana
Experiment type Expression profiling by high throughput sequencing
Summary Plant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differentiate. In this study, we used an integrated approach to elucidate the role of HECATE (HEC) genes in regulating developmental trajectories of shoot stem cells in Arabidopsis thaliana. Our work reveals that HEC function stabilizes cell fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem cell differentiation. Importantly, this activity is concomitant with the local modulation of cellular responses to cytokinin and auxin, two key phytohormones regulating cell behaviour. Mechanistically, we show that HEC factors directly modulate auxin signal transduction by physical interaction with MONOPTEROS (MP), a key regulator of auxin signalling, and thus interfere with the autocatalytic stabilization of auxin signalling.
Overall design p16:HEC1-linker-GR;inflorescence meristems; 3hours; mock1,mock2,mock3,dex1,dex2,dex3
Contributor(s) Lohmann JU, Gaillochet CJ
Citation(s) 29058667
Submission date Jan 31, 2017
Last update date May 15, 2019
Contact name Jan Lohmann
Phone +49186784234
Organization name Centre for Organismal Studies
Department Stem Cell Biology
Lab Jan Lohmann
Street address Im Neuenheimer Feld, 230
City Heidelberg
ZIP/Postal code 69120
Country Germany
Platforms (1)
GPL19580 Illumina NextSeq 500 (Arabidopsis thaliana)
Samples (6)
GSM2472786 mock1
GSM2472787 mock2
GSM2472788 mock3
This SubSeries is part of SuperSeries:
GSE94311 Control of plant cell fate transitions by transcriptional and hormonal signals
BioProject PRJNA369328
SRA SRP098619

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE94309_RAW.tar 660.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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