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| Status |
Public on Feb 22, 2018 |
| Title |
Identification of the RB loss-induced E2F1 cistrome in prostate cancer [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The retinoblastoma protein (RB) is preferentially lost in the progression to castrate resistant prostate cancer (CRPC). However, the alterations associated with such loss have been scantly described. The current study aims to provide molecular mechanisms underlying Rb loss-driven CRPC phenotypes.
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| |
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| Overall design |
Alterations in E2F1 binding upon RB loss were assessed in hormone deficient conditions through ChIP-Seq of shCON and shRB LNCaP prostate cancer cells.
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| Contributor(s) |
Knudsen KE, McNair C |
| Citation(s) |
29202480 |
| |
| Submission date |
Feb 15, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Christopher McNair |
| E-mail(s) |
christopher.mcnair@jefferson.edu
|
| Organization name |
Thomas Jefferson University
|
| Department |
Medical Oncology
|
| Street address |
833 Chestnut Street Ste 1140
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19107 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE94959 |
Identification of the RB loss-induced transcriptome and E2F1 cistrome in prostate cancer |
|
| Relations |
| BioProject |
PRJNA374919 |
| SRA |
SRP099930 |
