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Series GSE99250 Query DataSets for GSE99250
Status Public on Jun 12, 2017
Title Kmt2a and Kmt2b Control Memory Function via Different Transcriptional Programs
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary We have analyzed changes in histone 3 lysine 4 methylation (H3K4me) and gene expression resulting either from Kmt2a or Kmt2b knockdown in adult hippocampal CA neurons in mice. We implemented Cre/loxP-mediated conditional knockout strategy in order to knockdown either of these histone methyltransferases in excitatory forebrain neurons in adult mice.
 
Overall design Examination of H3K4me3 and H3K4me1 levels, and gene expression in hippocampal CA neurons of of adult Kmt2a cKO and Kmt2b cKO mice.
 
Contributor(s) Kerimoglu C, Fischer A
Citation(s) 28723559
Submission date May 24, 2017
Last update date Jul 25, 2021
Contact name Gaurav Jain
E-mail(s) gauravj49@gmail.com
Phone +49-551-39-61194
Organization name The German Center for Neurodegenerative Diseases (German: Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE)
Street address Von-Siebold-Str. 3a, Office no: 2.212
City Göttingen
State/province Lower Saxony
ZIP/Postal code 37075
Country Germany
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (72)
GSM2638085 H3K4me1_Kmt2a_Control_1
GSM2638086 H3K4me1_Kmt2a_Control_2
GSM2638087 H3K4me1_Kmt2a_Control_3
Relations
BioProject PRJNA387703
SRA SRP107938

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE99250_RAW.tar 52.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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