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Series GSE99566 Query DataSets for GSE99566
Status Public on Jun 01, 2019
Title c-MYC drives neuroblastoma tumorigenesis and retinoic acid resistance in zebrafish [ATAC-Seq]
Organism Danio rerio
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Neuroblastoma is an often intractable tumor that accounts for 15% of childhood cancer deaths. In addition to MYCN amplification in 20% of tumors, 11% express high levels of c-MYC (MYC) protein. To study this newly defined subgroup, we have created a novel transgenic zebrafish model in which overexpression of MYC in the peripheral sympathetic nervous system drives early-onset neuroblastoma.
Overall design ATAC-seq was performed on MYC and MYCN driven neuroblastoma tumors to determine chromatin accesibility in these cells
Contributor(s) Yang S, Zhou Y, Zon LI, Zimmerman MW, He S, Durbin AD, Look AT, Khan A, Zhang X, Zhu S, Liu Y, Zhang J
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Submission date Jun 01, 2017
Last update date Jul 25, 2021
Contact name Leonard Zon
Organization name Boston Children's Hospital
Department Oncology/Hematology
Street address 1 Blackfan Circle
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL20828 Illumina NextSeq 500 (Danio rerio)
Samples (2)
This SubSeries is part of SuperSeries:
GSE99572 c-MYC drives neuroblastoma tumorigenesis and retinoic acid resistance in zebrafish
BioProject PRJNA388954
SRA SRP108528

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Supplementary file Size Download File type/resource
GSE99566_RAW.tar 1.8 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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