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Series GSE99566 Query DataSets for GSE99566
Status Public on Jun 01, 2019
Title c-MYC drives neuroblastoma tumorigenesis and retinoic acid resistance in zebrafish [ATAC-Seq]
Organism Danio rerio
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Neuroblastoma is an often intractable tumor that accounts for 15% of childhood cancer deaths. In addition to MYCN amplification in 20% of tumors, 11% express high levels of c-MYC (MYC) protein. To study this newly defined subgroup, we have created a novel transgenic zebrafish model in which overexpression of MYC in the peripheral sympathetic nervous system drives early-onset neuroblastoma.
 
Overall design ATAC-seq was performed on MYC and MYCN driven neuroblastoma tumors to determine chromatin accesibility in these cells
 
Contributor(s) Yang S, Zhou Y, Zon LI, Zimmerman MW, He S, Durbin AD, Look AT, Khan A, Zhang X, Zhu S, Liu Y, Zhang J
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Submission date Jun 01, 2017
Last update date Jul 25, 2021
Contact name Leonard Zon
E-mail(s) zon@enders.tch.harvard.edu
Organization name Boston Children's Hospital
Department Oncology/Hematology
Street address 1 Blackfan Circle
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL20828 Illumina NextSeq 500 (Danio rerio)
Samples (2)
GSM2646576 MYCN_ATAC
GSM2646577 MYC_ATAC
This SubSeries is part of SuperSeries:
GSE99572 c-MYC drives neuroblastoma tumorigenesis and retinoic acid resistance in zebrafish
Relations
BioProject PRJNA388954
SRA SRP108528

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE99566_RAW.tar 1.8 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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