Male C57BL/6 mice were used in the ADX experiments. Bilateral ADX was performed in mice using the dorsal approach under ketamine/xylazine anesthesia (ketamine 91 mg/kg BW and xylazine 3.6 mg/kg BW, i.m.). The ADX mice were also fed standard chow (CE-2, Clea Japan Inc.) and 0.9% NaCl in their drinking water ad libitum.