SNCAIP synuclein alpha interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: SNCAIPprovided by HGNC
Official Full Name: synuclein alpha interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:11139
See related: Ensembl:ENSG00000064692 MIM:603779; AllianceGenome:HGNC:11139
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Sph1; SYPH1
Summary: This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Biased expression in ovary (RPKM 8.3), endometrium (RPKM 6.2) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q23.2

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (122311353..122464219)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (122828188..122981079)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (121647386..121799914)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicated that synphilin-1 may play neuroprotective roles in Parkinson Disease pathogenesis by inhibiting ROS production and apoptosis.
Title: Synphilin-1 has neuroprotective effects on MPP(+)-induced Parkinson's disease model cells by inhibiting ROS production and apoptosis.
Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin) was found in multiple system atrophy brains compared to control brain.
Title: Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.
Synphilin-1 binds ATP, but not CTP.
Title: Synphilin-1 binds ATP and regulates intracellular energy status.
Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.
Title: Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice.
Overexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity
Title: Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model.
Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP)-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.
Title: Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.
Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.
Title: Identification of Parkinson's disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson's disease patients.
Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation.
Title: α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.
Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.
Title: Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.
Knockdown of Herp gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.
Title: Deletion of Herp facilitates degradation of cytosolic proteins.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Parkinson disease, late-onset MedGen: C3160718 OMIM: 168600 GeneReviews: Parkinson Disease Overview, Gaucher Disease	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-144579 (e-PCR)
- UniSTS:172291

SNCAIP (e-PCR)
- UniSTS:504921

WI-13890 (e-PCR)
- UniSTS:6004

SHGC-77767 (e-PCR)
- UniSTS:100999

RH118488 (e-PCR)
- UniSTS:137883

SHGC-58617 (e-PCR)
- UniSTS:94430

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dopamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of inclusion body assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in neuronal cell body	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in presynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
located_in synaptic vesicle	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: synphilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011486.2 RefSeqGene

Range

5113..157095

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001242935.3 → NP_001229864.1 synphilin-1 isoform 1A

See identical proteins and their annotated locations for NP_001229864.1

Status: REVIEWED

Description

Transcript Variant: This variant (1A) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, and lacks two alternate exons in the central coding region, compared to variant 2. The encoded isoform (1A) has a distinct N-terminus and is shorter than isoform 2.

Source sequence(s)

BC040552, DQ227317, N21998

UniProtKB/TrEMBL

Q9NVG1

Conserved Domains (4) summary

cd00204
Location:28 → 144

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:28 → 121

Ank_2; Ankyrin repeats (3 copies)

pfam16700
Location:146 → 189

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:56 → 88

ANK; ANK repeat [structural motif]
NM_001308100.2 → NP_001295029.1 synphilin-1 isoform 2

See identical proteins and their annotated locations for NP_001295029.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AF076929, BC040552, N21998

Consensus CDS

CCDS78054.1

UniProtKB/TrEMBL

D6R9G8

Related

ENSP00000261367.7, ENST00000261367.11

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
NM_001308105.1 → NP_001295034.1 synphilin-1 isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (b) lacks an alternate in-frame exon in both the 5' and central coding regions, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.

Source sequence(s)

AB110789, AK299687, AK304646, AK310835, BC040552, N21998

UniProtKB/TrEMBL

D6R9G8

Related

ENSP00000422106.2, ENST00000509154.6

Conserved Domains (4) summary

cd00204
Location:335 → 450

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:335 → 427

Ank_2; Ankyrin repeats (3 copies)

pfam16700
Location:452 → 495

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:362 → 394

ANK; ANK repeat [structural motif]
NM_001308106.1 → NP_001295035.1 synphilin-1 isoform D

Status: REVIEWED

Description

Transcript Variant: This variant (d) lacks two alternate exons in the 5' coding region that result in translation initiation from a downstream start codon in a different reading frame, and it also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (D) has distinct N- and C-termini and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.

Source sequence(s)

AB110791, AK299687, AK304646, BC040552, N21998

UniProtKB/TrEMBL

B7Z995, D6RHZ0

Conserved Domains (4) summary

cd00204
Location:26 → 142

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:26 → 119

Ank_2; Ankyrin repeats (3 copies)

pfam16700
Location:144 → 187

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:54 → 86

ANK; ANK repeat [structural motif]
NM_001308107.2 → NP_001295036.1 synphilin-1 isoform E

Status: REVIEWED

Description

Transcript Variant: This variant (e) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks two alternate exons in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (E) has distinct N- and C-termini and is shorter than isoform 2.

Source sequence(s)

AI702863, AK304646, BC033743, BC040552, N21998

UniProtKB/TrEMBL

B7Z995, D6RHZ0

Conserved Domains (3) summary

sd00045
Location:56 → 88

ANK; ANK repeat [structural motif]

pfam12796
Location:28 → 121

Ank_2; Ankyrin repeats (3 copies)

pfam16700
Location:146 → 189

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
NM_001308108.1 → NP_001295037.1 synphilin-1 isoform F

Status: REVIEWED

Description

Transcript Variant: This variant (f) lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks an alternate exon in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (F) has distinct N- and C-termini and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.

Source sequence(s)

AB110793, AK299687, AK304646, BC040552, N21998

UniProtKB/TrEMBL

B7Z995, D6RHZ0

Conserved Domains (5) summary

cd00204
Location:39 → 204

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:85 → 181

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:44 → 99

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:206 → 249

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:43 → 76

ANK; ANK repeat [structural motif]
NM_001308109.2 → NP_001295038.1 synphilin-1 isoform G

Status: REVIEWED

Description

Transcript Variant: This variant (g) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks three alternate exons in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (G) has distinct N- and C-termini and is shorter than isoform 2.

Source sequence(s)

AK304646, BC040552, N21998

UniProtKB/TrEMBL

B7Z995, D6RHZ0

Conserved Domains (4) summary

sd00045
Location:52 → 83

ANK; ANK repeat [structural motif]

pfam13637
Location:53 → 106

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:108 → 151

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

cl39094
Location:3 → 83

Ank_2; Ankyrin repeats (3 copies)
NM_005460.4 → NP_005451.2 synphilin-1 isoform 1

See identical proteins and their annotated locations for NP_005451.2

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as variant a) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AF076929, AI702863, BC040552, N21998

Consensus CDS

CCDS4131.1

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8

Related

ENSP00000261368.8, ENST00000261368.13

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

RNA

NR_131761.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (c) includes two additional exons in the central region but lacks an alternate exon in the 3' region, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant lacks 5'-complete transcript support and thus its 5' end is incomplete.

Source sequence(s)

AB110790, AK299687, AK304646, BC040552, N21998
NR_131762.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and lacks five internal exons but includes an additional internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK299687, AK304646, BC040552, N21998

Related

ENST00000510658.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

122311353..122464219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006714734.3 → XP_006714797.1 synphilin-1 isoform X4

See identical proteins and their annotated locations for XP_006714797.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_047417925.1 → XP_047273881.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8
XM_047417932.1 → XP_047273888.1 synphilin-1 isoform X14

UniProtKB/TrEMBL

B7Z995, D6RHZ0
XM_024446267.2 → XP_024302035.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_024446266.2 → XP_024302034.1 synphilin-1 isoform X4

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_047417927.1 → XP_047273883.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8
XM_011543738.3 → XP_011542040.1 synphilin-1 isoform X1

See identical proteins and their annotated locations for XP_011542040.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
XM_047417915.1 → XP_047273871.1 synphilin-1 isoform X4

UniProtKB/TrEMBL

D6R9G8
XM_017010083.2 → XP_016865572.1 synphilin-1 isoform X9

UniProtKB/TrEMBL

Q9NVG1

Conserved Domains (4) summary

cd00204
Location:34 → 150

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:34 → 127

Ank_2; Ankyrin repeats (3 copies)

pfam16700
Location:152 → 195

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:62 → 94

ANK; ANK repeat [structural motif]
XM_024446269.2 → XP_024302037.1 synphilin-1 isoform X14

UniProtKB/TrEMBL

B7Z995, D6RHZ0

Conserved Domains (3) summary

cd00204
Location:34 → 150

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:62 → 94

ANK; ANK repeat [structural motif]

pfam16700
Location:152 → 195

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_047417911.1 → XP_047273867.1 synphilin-1 isoform X1

UniProtKB/TrEMBL

D6R9G8
XM_047417917.1 → XP_047273873.1 synphilin-1 isoform X5

UniProtKB/TrEMBL

D6R9G8
XM_005272139.2 → XP_005272196.1 synphilin-1 isoform X4

See identical proteins and their annotated locations for XP_005272196.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_047417923.1 → XP_047273879.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8
XM_011543739.2 → XP_011542041.1 synphilin-1 isoform X1

See identical proteins and their annotated locations for XP_011542041.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
XM_047417914.1 → XP_047273870.1 synphilin-1 isoform X4

UniProtKB/TrEMBL

D6R9G8
XM_024446268.2 → XP_024302036.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_011543743.3 → XP_011542045.1 synphilin-1 isoform X1

See identical proteins and their annotated locations for XP_011542045.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
XM_011543745.2 → XP_011542047.1 synphilin-1 isoform X4

See identical proteins and their annotated locations for XP_011542047.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_017010082.2 → XP_016865571.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_011543749.3 → XP_011542051.1 synphilin-1 isoform X9

UniProtKB/TrEMBL

Q9NVG1

Conserved Domains (4) summary

cd00204
Location:34 → 150

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:34 → 127

Ank_2; Ankyrin repeats (3 copies)

pfam16700
Location:152 → 195

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:62 → 94

ANK; ANK repeat [structural motif]
XM_011543737.3 → XP_011542039.1 synphilin-1 isoform X1

See identical proteins and their annotated locations for XP_011542039.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
XM_017010081.2 → XP_016865570.1 synphilin-1 isoform X5

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
XM_005272138.5 → XP_005272195.1 synphilin-1 isoform X4

See identical proteins and their annotated locations for XP_005272195.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (3) summary

cd00204
Location:345 → 510

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:349 → 382

ANK; ANK repeat [structural motif]

pfam16700
Location:512 → 555

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
XM_017010080.2 → XP_016865569.1 synphilin-1 isoform X3

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
XM_017010079.2 → XP_016865568.1 synphilin-1 isoform X2

UniProtKB/TrEMBL

D6R9G8
XM_047417929.1 → XP_047273885.1 synphilin-1 isoform X11

Related

ENSP00000378852.2, ENST00000395469.6
XM_017010084.2 → XP_016865573.1 synphilin-1 isoform X13
XM_047417926.1 → XP_047273882.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8
XM_047417916.1 → XP_047273872.1 synphilin-1 isoform X4

UniProtKB/TrEMBL

D6R9G8
XM_047417928.1 → XP_047273884.1 synphilin-1 isoform X9

UniProtKB/TrEMBL

Q9NVG1
XM_047417931.1 → XP_047273887.1 synphilin-1 isoform X14

UniProtKB/TrEMBL

B7Z995, D6RHZ0
XM_047417922.1 → XP_047273878.1 synphilin-1 isoform X7

UniProtKB/TrEMBL

D6R9G8
XM_047417930.1 → XP_047273886.1 synphilin-1 isoform X12

UniProtKB/TrEMBL

B7Z995, D6RHZ0
XM_047417920.1 → XP_047273876.1 synphilin-1 isoform X5

UniProtKB/TrEMBL

D6R9G8
XM_011543741.3 → XP_011542043.1 synphilin-1 isoform X1

See identical proteins and their annotated locations for XP_011542043.1

UniProtKB/TrEMBL

D6R9G8

Conserved Domains (5) summary

cd00204
Location:392 → 557

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:438 → 534

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:397 → 452

Ank_4; Ankyrin repeats (many copies)

pfam16700
Location:559 → 602

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:396 → 429

ANK; ANK repeat [structural motif]
XM_047417918.1 → XP_047273874.1 synphilin-1 isoform X5

UniProtKB/TrEMBL

D6R9G8
XM_047417913.1 → XP_047273869.1 synphilin-1 isoform X4

UniProtKB/TrEMBL

D6R9G8
XM_047417924.1 → XP_047273880.1 synphilin-1 isoform X8

UniProtKB/Swiss-Prot

D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5

UniProtKB/TrEMBL

D6R9G8
XM_047417921.1 → XP_047273877.1 synphilin-1 isoform X6

UniProtKB/TrEMBL

D6R9G8
XM_011543750.2 → XP_011542052.1 synphilin-1 isoform X10

UniProtKB/TrEMBL

Q9NVG1

Conserved Domains (4) summary

cd00204
Location:26 → 142

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:26 → 119

Ank_2; Ankyrin repeats (3 copies)

pfam16700
Location:144 → 187

SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

sd00045
Location:54 → 86

ANK; ANK repeat [structural motif]