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    ZNF284 zinc finger protein 284 [ Homo sapiens (human) ]

    Gene ID: 342909, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZNF284provided by HGNC
    Official Full Name
    zinc finger protein 284provided by HGNC
    Primary source
    HGNC:HGNC:13078
    See related
    Ensembl:ENSG00000186026 AllianceGenome:HGNC:13078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF284L
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in skin (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF284 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44072159..44089613)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46895045..46912496)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44576312..44593766)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14750 Neighboring gene zinc finger protein 222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 223 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene zinc finger protein 225

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp781F1775

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037813.4NP_001032902.1  zinc finger protein 284

      See identical proteins and their annotated locations for NP_001032902.1

      Status: VALIDATED

      Source sequence(s)
      AC084219, AY458845, BM989725
      Consensus CDS
      CCDS46099.1
      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Related
      ENSP00000411032.2, ENST00000421176.4
      Conserved Domains (3) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:209554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44072159..44089613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451486.2XP_024307254.1  zinc finger protein 284 isoform X1

      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Conserved Domains (3) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:209554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205225
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011526907.4XP_011525209.1  zinc finger protein 284 isoform X1

      See identical proteins and their annotated locations for XP_011525209.1

      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Conserved Domains (3) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:209554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205225
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_011526908.4XP_011525210.1  zinc finger protein 284 isoform X1

      See identical proteins and their annotated locations for XP_011525210.1

      UniProtKB/Swiss-Prot
      Q2VY69, Q86WM1
      Conserved Domains (3) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:209554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46895045..46912496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320843.1XP_054176818.1  zinc finger protein 284 isoform X1

    2. XM_054320842.1XP_054176817.1  zinc finger protein 284 isoform X1

    3. XM_054320841.1XP_054176816.1  zinc finger protein 284 isoform X1