Nradd neurotrophin receptor associated death domain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nraddprovided by RGD
Official Full Name: neurotrophin receptor associated death domainprovided by RGD
Primary source: RGD:708524
See related: EnsemblRapid:ENSRNOG00000020936 AllianceGenome:RGD:708524
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NRH2; PLAIDD
Summary: Enables neurotrophin p75 receptor binding activity. Involved in brain development; in utero embryonic development; and positive regulation of cell death. Located in cell body membrane and neuron projection membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 43.4), Adrenal (RPKM 36.1) and 9 other tissues See more
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Genomic context

Location:: 8q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (119478055..119481336, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110599667..110603068, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (118890402..118893712, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables death receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nerve growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin p75 receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope lumen	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: death domain-containing membrane protein NRADD

Names: neurotrophin receptor homolog-2; neurotrophin receptor-alike death domain protein; p75-like apoptosis-inducing death domain protein PLAIDD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139259.2 → NP_640352.1 death domain-containing membrane protein NRADD

See identical proteins and their annotated locations for NP_640352.1

Status: PROVISIONAL

Source sequence(s)

AF497263

UniProtKB/Swiss-Prot

G3V8U7, Q8K5A8, Q8K5A9

Related

ENSRNOP00000112382.1, ENSRNOT00000140942.1

Conserved Domains (1) summary

cd08311
Location:138 → 219

Death_p75NR; Death domain of p75 Neurotrophin Receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

119478055..119481336 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243921.4 → XP_006243983.1 death domain-containing membrane protein NRADD isoform X1

See identical proteins and their annotated locations for XP_006243983.1

UniProtKB/TrEMBL

A6I3F1, A6I3F2

Conserved Domains (1) summary

cd08311
Location:89 → 170

Death_p75NR; Death domain of p75 Neurotrophin Receptor