Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Huwe1provided by RGD
Official Full Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by RGD
Primary source: RGD:1561763
See related: EnsemblRapid:ENSRNOG00000061262 AllianceGenome:RGD:1561763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: URE-B1
Summary: Enables DNA binding activity. Predicted to be involved in several processes, including circadian regulation of gene expression; negative regulation of mitochondrial fusion; and protein ubiquitination. Located in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 342.2), Kidney (RPKM 310.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq13

Exon count:: 90

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (24350708..24480798)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (20873795..21001378)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (21474627..21603348)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the effects of Huwe1 on Notch1 signaling were completely abolished by knockdown of NMyc, indicating that Huwe1 may require NMyc to suppress the activation of the Notch1 signaling in L2.3 cells.
Title: Huwe1 is a novel mediator of protection of neural progenitor L2.3 cells against oxygen‑glucose deprivation injury.
Huwe1 knockdown increased Gadd45b, p-CREB and BDNF expression after brain neuron oxygen-glucose deprivation and reperfusion. It decreased methylation of the 5th CpG island (123 bp apart form BDNF IXa).
Title: Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_15341-15342:1017678837:1 (e-PCR)
- UniSTS:267819

RH142513 (e-PCR)
- UniSTS:231760

DXRat8 (e-PCR)
- UniSTS:119632

AU046935 (e-PCR)
- UniSTS:111002

AU048657 (e-PCR)
- UniSTS:145107

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info
enables histone ubiquitin ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type 2 mitophagy	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase HUWE1

Names: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; URE-binding protein 1; upstream regulatory element-binding protein 1

NP_001395856.1

EC 2.3.2.26

XP_063136267.1

EC 2.3.2.26

XP_063136268.1

EC 2.3.2.26

XP_063136269.1

EC 2.3.2.26

XP_063136270.1

EC 2.3.2.26

XP_063136271.1

EC 2.3.2.26

XP_063136272.1

EC 2.3.2.26

XP_063136273.1

EC 2.3.2.26

XP_063136274.1

EC 2.3.2.26

XP_063136275.1

EC 2.3.2.26

XP_063136276.1

EC 2.3.2.26

XP_063136277.1

EC 2.3.2.26

XP_063136278.1

EC 2.3.2.26

XP_063136279.1

EC 2.3.2.26

XP_063136280.1

EC 2.3.2.26

XP_063136281.1

EC 2.3.2.26

XP_063136282.1

EC 2.3.2.26

XP_063136283.1

EC 2.3.2.26

XP_063136284.1

EC 2.3.2.26

XP_063136285.1

EC 2.3.2.26

XP_063136286.1

EC 2.3.2.26

XP_063136287.1

EC 2.3.2.26

XP_063136288.1

EC 2.3.2.26

XP_063136289.1

EC 2.3.2.26

XP_063136290.1

EC 2.3.2.26

XP_063136291.1

EC 2.3.2.26

XP_063136292.1

EC 2.3.2.26

XP_063136293.1

EC 2.3.2.26

XP_063136294.1

EC 2.3.2.26

XP_063136295.1

EC 2.3.2.26

XP_063136296.1

EC 2.3.2.26

XP_063136297.1

EC 2.3.2.26

XP_063136298.1

EC 2.3.2.26

XP_063136299.1

EC 2.3.2.26

XP_063136300.1

EC 2.3.2.26

XP_063136301.1

EC 2.3.2.26

XP_063136302.1

EC 2.3.2.26

XP_063136303.1

EC 2.3.2.26

XP_063136304.1

EC 2.3.2.26

XP_063136305.1

EC 2.3.2.26

XP_063136306.1

EC 2.3.2.26

XP_063136307.1

EC 2.3.2.26

XP_063136308.1

EC 2.3.2.26

XP_063136309.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001408927.1 → NP_001395856.1 E3 ubiquitin-protein ligase HUWE1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I6A634

Related

ENSRNOP00000088915.1, ENSRNOT00000109386.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

24350708..24480798

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280233.1 → XP_063136303.1 E3 ubiquitin-protein ligase HUWE1 isoform X14

UniProtKB/TrEMBL

A0A8I6A634
XM_063280199.1 → XP_063136269.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280222.1 → XP_063136292.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593
XM_063280208.1 → XP_063136278.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280232.1 → XP_063136302.1 E3 ubiquitin-protein ligase HUWE1 isoform X14

UniProtKB/TrEMBL

A0A8I6A634

Related

ENSRNOP00000069644.3, ENSRNOT00000081037.3
XM_063280209.1 → XP_063136279.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280198.1 → XP_063136268.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280216.1 → XP_063136286.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593
XM_063280204.1 → XP_063136274.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280217.1 → XP_063136287.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593
XM_063280230.1 → XP_063136300.1 E3 ubiquitin-protein ligase HUWE1 isoform X14

UniProtKB/TrEMBL

A0A8I6A634
XM_063280207.1 → XP_063136277.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280202.1 → XP_063136272.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280218.1 → XP_063136288.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593
XM_063280205.1 → XP_063136275.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280201.1 → XP_063136271.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280215.1 → XP_063136285.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593
XM_063280206.1 → XP_063136276.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280221.1 → XP_063136291.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593
XM_063280231.1 → XP_063136301.1 E3 ubiquitin-protein ligase HUWE1 isoform X14

UniProtKB/TrEMBL

A0A8I6A634
XM_063280200.1 → XP_063136270.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280220.1 → XP_063136290.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593
XM_063280228.1 → XP_063136298.1 E3 ubiquitin-protein ligase HUWE1 isoform X12
XM_063280197.1 → XP_063136267.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280210.1 → XP_063136280.1 E3 ubiquitin-protein ligase HUWE1 isoform X2
XM_063280225.1 → XP_063136295.1 E3 ubiquitin-protein ligase HUWE1 isoform X9
XM_063280226.1 → XP_063136296.1 E3 ubiquitin-protein ligase HUWE1 isoform X10
XM_063280227.1 → XP_063136297.1 E3 ubiquitin-protein ligase HUWE1 isoform X11
XM_063280235.1 → XP_063136305.1 E3 ubiquitin-protein ligase HUWE1 isoform X16

Related

ENSRNOP00000071818.3, ENSRNOT00000090890.3
XM_063280211.1 → XP_063136281.1 E3 ubiquitin-protein ligase HUWE1 isoform X3
XM_063280212.1 → XP_063136282.1 E3 ubiquitin-protein ligase HUWE1 isoform X4
XM_063280213.1 → XP_063136283.1 E3 ubiquitin-protein ligase HUWE1 isoform X5
XM_063280223.1 → XP_063136293.1 E3 ubiquitin-protein ligase HUWE1 isoform X7
XM_063280237.1 → XP_063136307.1 E3 ubiquitin-protein ligase HUWE1 isoform X18
XM_063280224.1 → XP_063136294.1 E3 ubiquitin-protein ligase HUWE1 isoform X8
XM_063280229.1 → XP_063136299.1 E3 ubiquitin-protein ligase HUWE1 isoform X13
XM_063280214.1 → XP_063136284.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593

Related

ENSRNOP00000095129.1, ENSRNOT00000098599.2
XM_063280239.1 → XP_063136309.1 E3 ubiquitin-protein ligase HUWE1 isoform X20
XM_063280236.1 → XP_063136306.1 E3 ubiquitin-protein ligase HUWE1 isoform X17
XM_063280234.1 → XP_063136304.1 E3 ubiquitin-protein ligase HUWE1 isoform X15
XM_063280238.1 → XP_063136308.1 E3 ubiquitin-protein ligase HUWE1 isoform X19
XM_063280203.1 → XP_063136273.1 E3 ubiquitin-protein ligase HUWE1 isoform X1
XM_063280219.1 → XP_063136289.1 E3 ubiquitin-protein ligase HUWE1 isoform X6

UniProtKB/Swiss-Prot

A0A8I6APS3, P51593