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    Cbx7 chromobox 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362962, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cbx7provided by RGD
    Official Full Name
    chromobox 7provided by RGD
    Primary source
    RGD:735027
    See related
    EnsemblRapid:ENSRNOG00000016875 AllianceGenome:RGD:735027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Involved in developmental process involved in reproduction; positive regulation of transcription elongation by RNA polymerase II; and response to xenobiotic stimulus. Predicted to be located in cytosol; heterochromatin; and nucleoplasm. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 91.5), Lung (RPKM 84.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cbx7 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113341030..113358716, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111460656..111479231, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121136067..121153503, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547383 Neighboring gene U6 spliceosomal RNA Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3 Neighboring gene uncharacterized LOC120093692 Neighboring gene small nucleolar RNA U109 Neighboring gene platelet derived growth factor subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway. Zhang F, et al. J Biosci, 2022. PMID 36222130
    2. CBX7 Expression in Oncocytic Thyroid Neoplastic Lesions (Hürthle Cell Adenomas and Carcinomas). Monaco M, et al. Eur Thyroid J, 2014 Dec. PMID 25759796, Free PMC Article
    3. Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding. Klauke K, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434821, Free PMC Article
    4. Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Karamitopoulou E, et al. Eur J Cancer, 2010 May. PMID 20185297
    5. Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein. Mansueto G, et al. Genes Cancer, 2010 Mar. PMID 21779448, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury.
      Title: Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury.
    2. Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway.
      Title: Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental process involved in reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sebaceous gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PRC1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromobox protein homolog 7
    Names
    chromobox homolog 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199117.2 → NP_954548.1  chromobox protein homolog 7

      See identical proteins and their annotated locations for NP_954548.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P60889
      UniProtKB/TrEMBL
      A6HSV0
      Conserved Domains (1) summary
      pfam00385
      Location:13 → 60
      Chromo; Chromo (CHRromatin Organization MOdifier) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      113341030..113358716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079593.2 → XP_038935521.1  chromobox protein homolog 7 isoform X7

      UniProtKB/TrEMBL
      A0A8L2UR72
      Related
      ENSRNOP00000074584.2, ENSRNOT00000077731.3

    2. XM_039079592.2 → XP_038935520.1  chromobox protein homolog 7 isoform X6

      Conserved Domains (2) summary
      cd18646
      Location:7 → 62
      CD_Cbx7; chromodomain of chromobox homolog 7
      pfam17218
      Location:115 → 146
      CBX7_C; CBX family C-terminal motif

    3. XM_039079591.2 → XP_038935519.1  chromobox protein homolog 7 isoform X4

      Conserved Domains (2) summary
      cd18646
      Location:7 → 62
      CD_Cbx7; chromodomain of chromobox homolog 7
      pfam17218
      Location:150 → 181
      CBX7_C; CBX family C-terminal motif

    4. XM_006242022.5 → XP_006242084.1  chromobox protein homolog 7 isoform X2

      Conserved Domains (1) summary
      smart00298
      Location:10 → 62
      CHROMO; Chromatin organization modifier domain

    5. XM_006242020.5 → XP_006242082.1  chromobox protein homolog 7 isoform X1

      See identical proteins and their annotated locations for XP_006242082.1

      UniProtKB/TrEMBL
      A0A8L2QCQ7, A6HSV1
      Related
      ENSRNOP00000022631.6, ENSRNOT00000022631.8
      Conserved Domains (1) summary
      smart00298
      Location:10 → 62
      CHROMO; Chromatin organization modifier domain

    6. XM_039079590.2 → XP_038935518.1  chromobox protein homolog 7 isoform X3

      Conserved Domains (1) summary
      pfam17218
      Location:155 → 186
      CBX7_C; CBX family C-terminal motif

    7. XM_063263925.1 → XP_063119995.1  chromobox protein homolog 7 isoform X5

    8. XM_006242021.5 → XP_006242083.1  chromobox protein homolog 7 isoform X1

      See identical proteins and their annotated locations for XP_006242083.1

      UniProtKB/TrEMBL
      A0A8L2QCQ7, A6HSV1
      Conserved Domains (1) summary
      smart00298
      Location:10 → 62
      CHROMO; Chromatin organization modifier domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60889.1 GenPept UniProtKB/Swiss-Prot:P60889

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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