Pelo pelota mRNA surveillance and ribosome rescue factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Peloprovided by RGD
Official Full Name: pelota mRNA surveillance and ribosome rescue factorprovided by RGD
Primary source: RGD:1359591
See related: EnsemblRapid:ENSRNOG00000061128 AllianceGenome:RGD:1359591
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ribosome binding activity and stalled ribosome sensor activity. Predicted to be involved in nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process, no-go decay; and rescue of stalled ribosome. Predicted to act upstream of or within several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 171.0), Heart (RPKM 147.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (48530902..48532670, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (46797853..46799621, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (47266758..47268526, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside-triphosphatase regulator activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables stalled ribosome sensor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA surveillance	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
involved_in nonfunctional rRNA decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in ribosome disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Dom34-Hbs1 complex	ISO Inferred from Sequence Orthology more info
part_of Dom34-Hbs1 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein pelota homolog

Names: pelota homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007634.1 → NP_001007635.1 protein pelota homolog

See identical proteins and their annotated locations for NP_001007635.1

Status: PROVISIONAL

Source sequence(s)

BC083637

UniProtKB/Swiss-Prot

Q5XIP1

Related

ENSRNOP00000075562.1, ENSRNOT00000091499.3

Conserved Domains (1) summary

COG1537
Location:1 → 371

PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]