Trim27 tripartite motif-containing 27 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim27provided by RGD
Official Full Name: tripartite motif-containing 27provided by RGD
Primary source: RGD:1310105
See related: EnsemblRapid:ENSRNOG00000055917 AllianceGenome:RGD:1310105
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rfp1
Summary: Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; defense response to other organism; and regulation of gene expression. Predicted to act upstream of or within negative regulation of gene expression, epigenetic and positive regulation of actin nucleation. Predicted to be located in endosome; fibrillar center; and nuclear membrane. Predicted to be part of retromer complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIM27 (tripartite motif containing 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 189.8), Testes (RPKM 171.0) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (48233999..48246348, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (43538282..43550633, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (45613863..45626212, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis.
Title: Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis.
Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways.
Title: Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways.
Data showed that Trim27 deficiency decreases apoptosis and protects dopaminergic neurons in MPTP poisoning, suggesting that Trim27 may be an effective potential target during the treatment of Parkinson's disease
Title: Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

TRIM27 (e-PCR)
- UniSTS:505620

RH128894 (e-PCR)
- UniSTS:212202

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: zinc finger protein RFP

Names: ret finger protein 1; tripartite motif protein 27

NP_001128446.1

EC 2.3.2.27

XP_038951445.1

EC 2.3.2.27

XP_038951446.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134974.1 → NP_001128446.1 zinc finger protein RFP

See identical proteins and their annotated locations for NP_001128446.1

Status: PROVISIONAL

Source sequence(s)

BC169072

UniProtKB/TrEMBL

A0A0G2K8V4, A0A8I6A5I2, B5DFI5

Related

ENSRNOP00000074750.1, ENSRNOT00000077363.3

Conserved Domains (4) summary

COG1196
Location:140 → 312

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd15814
Location:315 → 491

SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)

cd16594
Location:13 → 57

RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

cd19762
Location:94 → 137

Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

48233999..48246348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095517.2 → XP_038951445.1 zinc finger protein RFP isoform X1

Conserved Domains (1) summary

cl02614
Location:139 → 315

SPRY; SPRY domain
XM_039095518.2 → XP_038951446.1 zinc finger protein RFP isoform X1

Conserved Domains (1) summary

cl02614
Location:139 → 315

SPRY; SPRY domain

RNA

XR_005495255.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106115.1: Suppressed sequence

Description

NM_001106115.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.