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    Zfp110 zinc finger protein 110 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308362, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp110provided by RGD
    Official Full Name
    zinc finger protein 110provided by RGD
    Primary source
    RGD:1306339
    See related
    Ensembl:ENSRNOG00000031328 AllianceGenome:RGD:1306339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nrif1
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and neurotrophin p75 receptor binding activity. Predicted to be involved in several processes, including neuron apoptotic process; regulation of JNK cascade; and regulation of histone H3-K9 trimethylation. Predicted to act upstream of or within extrinsic apoptotic signaling pathway and retinal cell apoptotic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human ZNF274 (zinc finger protein 274). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 147.7), Thymus (RPKM 145.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp110 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82509563..82533294)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73445303..73461112)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65741769..65757709, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 2 receptor, 36 Neighboring gene microRNA 295-2 Neighboring gene zinc finger and SCAN domain containing 18 Neighboring gene zinc finger protein 329 Neighboring gene zinc finger protein 8 Neighboring gene zinc finger and SCAN domain containing 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. Linggi MS, et al. J Biol Chem, 2005 Apr 8. PMID 15668238
    2. Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Benzel I, et al. Gene, 2001 Dec 27. PMID 11750124
    3. ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. Frietze S, et al. PLoS One, 2010 Dec 8. PMID 21170338, Free PMC Article
    4. The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death. Casademunt E, et al. EMBO J, 1999 Nov 1. PMID 10545116, Free PMC Article
    5. ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Valle-García D, et al. Epigenetics, 2016 Jun 2. PMID 27029610, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurotrophin p75 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinal cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neurotrophin receptor-interacting factor 1
    Names
    zinc finger protein 274

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024775.1 → NP_001019946.1  neurotrophin receptor-interacting factor 1

      See identical proteins and their annotated locations for NP_001019946.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097420
      UniProtKB/Swiss-Prot
      Q4V8E9
      UniProtKB/TrEMBL
      A0A8L2UK63
      Related
      ENSRNOP00000026298.6, ENSRNOT00000026298.6
      Conserved Domains (9) summary
      smart00431
      Location:157 → 285
      SCAN; leucine rich region
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:704 → 761
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:653 → 672
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:762 → 784
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:278 → 317
      KRAB; KRAB box
      pfam02023
      Location:157 → 240
      SCAN; SCAN domain
      pfam13465
      Location:776 → 801
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      82509563..82533294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228111.5 → XP_006228173.1  neurotrophin receptor-interacting factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UK63
      Conserved Domains (9) summary
      smart00431
      Location:200 → 328
      SCAN; leucine rich region
      smart00349
      Location:57 → 116
      KRAB; krueppel associated box
      COG5048
      Location:747 → 804
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:779 → 799
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:696 → 715
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:805 → 827
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:321 → 360
      KRAB; KRAB box
      pfam02023
      Location:200 → 283
      SCAN; SCAN domain
      pfam13465
      Location:819 → 844
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017589113.3 → XP_017444602.1  neurotrophin receptor-interacting factor 1 isoform X3

    3. XM_006228112.5 → XP_006228174.1  neurotrophin receptor-interacting factor 1 isoform X2

      See identical proteins and their annotated locations for XP_006228174.1

      UniProtKB/Swiss-Prot
      Q4V8E9
      UniProtKB/TrEMBL
      A0A8L2UK63
      Conserved Domains (9) summary
      smart00431
      Location:157 → 285
      SCAN; leucine rich region
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:704 → 761
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:653 → 672
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:762 → 784
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:278 → 317
      KRAB; KRAB box
      pfam02023
      Location:157 → 240
      SCAN; SCAN domain
      pfam13465
      Location:776 → 801
      zf-H2C2_2; Zinc-finger double domain

    4. XM_063261278.1 → XP_063117348.1  neurotrophin receptor-interacting factor 1 isoform X4

    5. XM_063261277.1 → XP_063117347.1  neurotrophin receptor-interacting factor 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8E9.1 GenPept UniProtKB/Swiss-Prot:Q4V8E9

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