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    Elp5 elongator acetyltransferase complex subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287446, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Elp5provided by RGD
    Official Full Name
    elongator acetyltransferase complex subunit 5provided by RGD
    Primary source
    RGD:1303303
    See related
    EnsemblRapid:ENSRNOG00000027628 AllianceGenome:RGD:1303303
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DERP6; Rai12
    Summary
    Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol and nucleus. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 79.4), Adrenal (RPKM 78.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elp5 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55191223..55202949, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54692526..54704255, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56578980..56590706, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cofilin-1-like Neighboring gene claudin 7 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene GABA type A receptor-associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Close P, et al. J Biol Chem, 2012 Sep 21. PMID 22854966, Free PMC Article
    2. Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control. Chen VC, et al. J Proteome Res, 2012 Dec 7. PMID 23106098
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongator holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of elongator holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    elongator complex protein 5
    Names
    S-phase 2 protein
    dermal papilla derived protein 6
    dermal papilla-derived protein 6 homolog
    retinoic acid induced 12
    retinoic acid-induced protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001718.1 → NP_001001718.1  elongator complex protein 5

      See identical proteins and their annotated locations for NP_001001718.1

      Status: PROVISIONAL

      Source sequence(s)
      AY623900
      UniProtKB/Swiss-Prot
      Q6IUP3
      UniProtKB/TrEMBL
      A6HFY9
      Conserved Domains (1) summary
      cd19496
      Location:30 → 192
      Elp5; Elongator subcomplex subunit Elp5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55191223..55202949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597092.1 → XP_017452581.1  elongator complex protein 5 isoform X1

      UniProtKB/TrEMBL
      B0BMU7
      Related
      ENSRNOP00000035345.5, ENSRNOT00000032481.7
      Conserved Domains (1) summary
      pfam10483
      Location:19 → 302
      Elong_Iki1; Elongator subunit Iki1

    2. XM_063268644.1 → XP_063124714.1  elongator complex protein 5 isoform X3

      UniProtKB/TrEMBL
      A6HFZ1

    3. XM_039085463.2 → XP_038941391.1  elongator complex protein 5 isoform X2

      Conserved Domains (1) summary
      cd19496
      Location:30 → 160
      Elp5; Elongator subcomplex subunit Elp5

    RNA

    1. XR_005489736.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IUP3.1 GenPept UniProtKB/Swiss-Prot:Q6IUP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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