Dock5 dedicator of cytokinesis 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dock5provided by RGD
Official Full Name: dedicator of cytokinesis 5provided by RGD
Primary source: RGD:1306872
See related: EnsemblRapid:ENSRNOG00000024703 AllianceGenome:RGD:1306872
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; positive regulation of cell migration; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within bone remodeling and podosome assembly. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human DOCK5 (dedicator of cytokinesis 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 115.1), Lung (RPKM 97.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 54

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (46155124..46334127, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (41979728..42158733, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (44449108..44627774, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372012.1 → NP_001358941.1 dedicator of cytokinesis protein 5

Status: VALIDATED

Source sequence(s)

FQ131230, JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I5ZK89, A0A8I6ARJ2

Related

ENSRNOP00000077193.1, ENSRNOT00000112046.2

Conserved Domains (4) summary

cd11708
Location:1238 → 1637

DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5

cd12051
Location:12 → 67

SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5

pfam16172
Location:75 → 434

DOCK_N; DOCK N-terminus

cl14603
Location:442 → 637

C2; C2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

46155124..46334127 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093338.2 → XP_038949266.1 dedicator of cytokinesis protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6ARJ2

Related

ENSRNOP00000055674.5, ENSRNOT00000058887.7

Conserved Domains (3) summary

cd11708
Location:1205 → 1604

DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5

pfam16172
Location:42 → 401

DOCK_N; DOCK N-terminus

cl14603
Location:409 → 604

C2; C2 domain
XM_063274295.1 → XP_063130365.1 dedicator of cytokinesis protein 5 isoform X1
XM_039093339.2 → XP_038949267.1 dedicator of cytokinesis protein 5 isoform X2

Conserved Domains (4) summary

pfam16172
Location:75 → 434

DOCK_N; DOCK N-terminus

cl06123
Location:1238 → 1534

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

cl14603
Location:442 → 637

C2; C2 domain

cl17036
Location:12 → 67

SH3; Src Homology 3 domain superfamily

RNA

XR_010057823.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107274.1: Suppressed sequence

Description

NM_001107274.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DOCK5 (GeneID:80005).