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    Gga1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300066, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Gga1provided by RGD
    Official Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 1provided by RGD
    Primary source
    RGD:1307770
    See related
    Ensembl:ENSRNOG00000008897 AllianceGenome:RGD:1307770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in several processes, including protein localization to cell periphery; protein localization to cell surface; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within positive regulation of protein catabolic process and toxin transport. Predicted to be located in Golgi apparatus; early endosome; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 73.6), Kidney (RPKM 50.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gga1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112316530..112332249)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110436071..110451790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120102596..120119738)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 1 Neighboring gene galectin 2 Neighboring gene uncharacterized LOC134479608 Neighboring gene uncharacterized LOC120093687 Neighboring gene SH3-domain binding protein 1 Neighboring gene uncharacterized LOC134479755 Neighboring gene pyridoxal phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of coat proteins changes during postnatal development in selected areas of the rat brain. Borgonovo J, et al. Int J Dev Neurosci, 2012 Jun. PMID 22306374
    2. GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Wahle T, et al. Mol Cell Neurosci, 2005 Jul. PMID 15886016
    3. Crystal structure of the human GGA1 GAT domain. Zhu G, et al. Biochemistry, 2003 Jun 3. PMID 12767220
    4. Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. Suer S, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12668765, Free PMC Article
    5. Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport. Shiba T, et al. Nat Struct Biol, 2003 May. PMID 12679809

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109601

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-binding protein GGA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011994.2 → NP_001011994.1  ADP-ribosylation factor-binding protein GGA1 isoform 2

      See identical proteins and their annotated locations for NP_001011994.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6GEK9, Q5FVF3
      Related
      ENSRNOP00000086095.1, ENSRNOT00000113842.1
      Conserved Domains (4) summary
      smart00809
      Location:440 → 554
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14239
      Location:137 → 225
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl00753
      Location:107 → 161
      DUF327; Protein of unknown function (DUF327)
      cl02544
      Location:1 → 74
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

    2. NM_001399734.1 → NP_001386663.1  ADP-ribosylation factor-binding protein GGA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6GLY6, F7FHC7
      Related
      ENSRNOP00000096170.1, ENSRNOT00000098550.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112316530..112332249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263316.1 → XP_063119386.1  ADP-ribosylation factor-binding protein GGA1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GEK9, Q5FVF3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
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