U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ptpn13 protein tyrosine phosphatase, non-receptor type 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498331, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Symbol
    Ptpn13provided by RGD
    Full Name
    protein tyrosine phosphatase, non-receptor type 13provided by RGD
    Primary source
    RGD:1563360
    See related
    Ensembl:ENSRNOG00000002061 AllianceGenome:RGD:1563360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ptp; Ptp-bl
    Summary
    Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of protein phosphorylation; peptidyl-tyrosine dephosphorylation; and regulation of phosphatidylinositol 3-kinase signaling. Located in cell body and neuron projection. Orthologous to human PTPN13 (protein tyrosine phosphatase non-receptor type 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 261.9), Lung (RPKM 157.6) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ptpn13 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (6412841..6587238, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (6108202..6282619, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7688551..7863664, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546534 Neighboring gene solute carrier family 10 member 6 Neighboring gene uncharacterized LOC134481819 Neighboring gene uncharacterized LOC134481699 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4-like 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers. Chen J, et al. Cancer Cell Int, 2020. PMID 32536826, Free PMC Article
    2. Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin. Huang W, et al. Oncotarget, 2018 May 25. PMID 29899829, Free PMC Article
    3. The nonreceptor-type tyrosine phosphatase PTPN13 is a tumor suppressor gene in non-small cell lung cancer. Scrima M, et al. Am J Pathol, 2012 Mar. PMID 22245727
    4. FAP-1 and NF-κB expressions in oral squamous cell carcinoma as potential markers for chemo-radio sensitivity and prognosis. Nariai Y, et al. Int J Oral Maxillofac Surg, 2011 Apr. PMID 21176871
    5. The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. Welters HJ, et al. J Endocrinol, 2008 Jun. PMID 18413347

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTP-BL plays an important role in the regulation of cell cycle progression in pancreatic beta-cells, and that it interacts functionally with components of the Wnt signalling pathway.
      Title: The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol 3-kinase regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of excitatory synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 13
    Names
    protein Tyr phosphatase
    tyrosine-protein phosphatase non-receptor type 13-like
    NP_001094259.1
    XP_038948202.1
    XP_038948204.1
    XP_063129523.1
    XP_063129524.1
    XP_063129525.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100789.1 → NP_001094259.1  tyrosine-protein phosphatase non-receptor type 13

      See identical proteins and their annotated locations for NP_001094259.1

      Status: VALIDATED

      Source sequence(s)
      CH474022
      UniProtKB/TrEMBL
      A0A0G2K1K1, A6K5V1
      Related
      ENSRNOP00000057876.3, ENSRNOT00000061162.5
      Conserved Domains (10) summary
      smart00194
      Location:2185 → 2437
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00228
      Location:1488 → 1578
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:566 → 774
      B41; Band 4.1 homologues
      smart00750
      Location:3 → 190
      KIND; kinase non-catalytic C-lobe domain
      cd00047
      Location:2211 → 2437
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:1082 → 1166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:661 → 774
      FERM_M; FERM central domain
      pfam09379
      Location:569 → 631
      FERM_N; FERM N-terminal domain
      pfam16599
      Location:1168 → 1356
      PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
      cl17171
      Location:770 → 870
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      6412841..6587238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092276.2 → XP_038948204.1  tyrosine-protein phosphatase non-receptor type 13 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6L8
      Related
      ENSRNOP00000087844.1
      Conserved Domains (8) summary
      smart00228
      Location:1299 → 1389
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:566 → 774
      B41; Band 4.1 homologues
      smart00750
      Location:3 → 190
      KIND; kinase non-catalytic C-lobe domain
      cd00992
      Location:893 → 977
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd17195
      Location:564 → 659
      FERM_F1_PTPN13; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
      cd14597
      Location:2022 → 2255
      PTPc-N13; catalytic domain of tyrosine-protein phosphatase non-receptor type 13
      pfam16599
      Location:979 → 1167
      PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
      cl17171
      Location:770 → 870
      PH-like; Pleckstrin homology-like domain

    2. XM_063273454.1 → XP_063129524.1  tyrosine-protein phosphatase non-receptor type 13 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K1K1

    3. XM_063273453.1 → XP_063129523.1  tyrosine-protein phosphatase non-receptor type 13 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1K1, G3V9S3

    4. XM_039092274.2 → XP_038948202.1  tyrosine-protein phosphatase non-receptor type 13 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1K1
      Conserved Domains (8) summary
      smart00228
      Location:1493 → 1583
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      smart00295
      Location:566 → 774
      B41; Band 4.1 homologues
      smart00750
      Location:3 → 190
      KIND; kinase non-catalytic C-lobe domain
      cd00992
      Location:1082 → 1166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd17195
      Location:564 → 659
      FERM_F1_PTPN13; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
      cd14597
      Location:2216 → 2449
      PTPc-N13; catalytic domain of tyrosine-protein phosphatase non-receptor type 13
      pfam16599
      Location:1168 → 1356
      PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
      cl17171
      Location:770 → 870
      PH-like; Pleckstrin homology-like domain

    5. XM_063273455.1 → XP_063129525.1  tyrosine-protein phosphatase non-receptor type 13 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K1K1, A0A8I5ZZK7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools