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    Arb2a ARB2 cotranscriptional regulator A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294606, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arb2aprovided by RGD
    Official Full Name
    ARB2 cotranscriptional regulator Aprovided by RGD
    Primary source
    RGD:1305526
    See related
    EnsemblRapid:ENSRNOG00000013844 AllianceGenome:RGD:1305526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam172a; RGD1305526
    Summary
    Predicted to contribute to siRNA binding activity. Predicted to be involved in neural crest cell development; regulation of alternative mRNA splicing, via spliceosome; and regulatory ncRNA-mediated heterochromatin formation. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human ARB2A (ARB2 cotranscriptional regulator A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 168.8), Lung (RPKM 111.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arb2a in Genome Data Viewer
    Location:
    2q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (9289694..9753991)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (7553873..8018183)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (4942795..5547744)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene KIAA0825 homolog Neighboring gene ribosomal protein L17, pseudogene 12 Neighboring gene ribosomal protein L35, pseudogene 3 Neighboring gene mRNA turnover protein 4 homolog Neighboring gene RNA, U6 small nuclear 259 Neighboring gene POU domain class 5, transcription factor 2 Neighboring gene protein FAM98B-like Neighboring gene nuclear receptor subfamily 2, group F, member 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell. Andersen B, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 7902581, Free PMC Article
    2. Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Bélanger C, et al. Proc Natl Acad Sci U S A, 2018 Jan 23. PMID 29311329, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to siRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cotranscriptional regulator ARB2A
    Names
    cotranscriptional regulator FAM172A
    family with sequence similarity 172, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106401.1 → NP_001099871.1  cotranscriptional regulator ARB2A

      See identical proteins and their annotated locations for NP_001099871.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473955
      UniProtKB/TrEMBL
      A0A1W2Q630, A0A8I6ALB8, A6I4H2
      Conserved Domains (1) summary
      pfam09757
      Location:32 → 176
      Arb2; Arb2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      9289694..9753991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281474.1 → XP_063137544.1  cotranscriptional regulator ARB2A isoform X6

    2. XM_063281479.1 → XP_063137549.1  cotranscriptional regulator ARB2A isoform X11

    3. XM_063281481.1 → XP_063137551.1  cotranscriptional regulator ARB2A isoform X13

    4. XM_039101899.2 → XP_038957827.1  cotranscriptional regulator ARB2A isoform X3

    5. XM_063281470.1 → XP_063137540.1  cotranscriptional regulator ARB2A isoform X2

    6. XM_063281475.1 → XP_063137545.1  cotranscriptional regulator ARB2A isoform X7

    7. XM_063281483.1 → XP_063137553.1  cotranscriptional regulator ARB2A isoform X16

    8. XM_039101894.2 → XP_038957822.1  cotranscriptional regulator ARB2A isoform X1

      Related
      ENSRNOP00000076112.2, ENSRNOT00000093741.3

    9. XM_008760626.4 → XP_008758848.2  cotranscriptional regulator ARB2A isoform X14

      UniProtKB/TrEMBL
      A0A8I5Y692
      Related
      ENSRNOP00000077745.1, ENSRNOT00000099388.2

    10. XM_063281472.1 → XP_063137542.1  cotranscriptional regulator ARB2A isoform X4

    11. XM_063281473.1 → XP_063137543.1  cotranscriptional regulator ARB2A isoform X4

    12. XM_063281471.1 → XP_063137541.1  cotranscriptional regulator ARB2A isoform X4

    13. XM_039101903.2 → XP_038957831.1  cotranscriptional regulator ARB2A isoform X5

      UniProtKB/TrEMBL
      A0A1W2Q607, A0A8I6GH74
      Related
      ENSRNOP00000089372.1, ENSRNOT00000095380.2

    14. XM_063281480.1 → XP_063137550.1  cotranscriptional regulator ARB2A isoform X12

    15. XM_063281477.1 → XP_063137547.1  cotranscriptional regulator ARB2A isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZU52
      Related
      ENSRNOP00000082005.1, ENSRNOT00000103663.2

    16. XM_063281484.1 → XP_063137554.1  cotranscriptional regulator ARB2A isoform X17

      UniProtKB/TrEMBL
      A0A8I6AKD2

    17. XM_063281482.1 → XP_063137552.1  cotranscriptional regulator ARB2A isoform X15

    18. XM_063281485.1 → XP_063137555.1  cotranscriptional regulator ARB2A isoform X18

    19. XM_063281478.1 → XP_063137548.1  cotranscriptional regulator ARB2A isoform X10

    20. XM_063281476.1 → XP_063137546.1  cotranscriptional regulator ARB2A isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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