Eva1a eva-1 homolog A, regulator of programmed cell death [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Eva1aprovided by RGD
Full Name: eva-1 homolog A, regulator of programmed cell deathprovided by RGD
Primary source: RGD:1559797
See related: Ensembl:ENSRNOG00000007118 AllianceGenome:RGD:1559797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam176a; Tmem166; RGD1559797
Summary: Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 81.3), Liver (RPKM 66.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (116151595..116200827)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (114593773..114643011)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (112714023..112823659)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study suggested that MEM166 induced autophagy and apoptosis may in fact play a significant role in the cell death process following MCAO injury and its mediation may be through the Bcl-2. By blocking the activity of TMEM166 using siRNA
Title: Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

D4Rat176 (e-PCR), detects polymorphism
- UniSTS:227736

D4Rat268 (e-PCR), detects polymorphism
- UniSTS:227811

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein eva-1 homolog A

Names: family with sequence similarity 176, member A; protein FAM176A; transmembrane protein 166

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109243.1 → NP_001102713.1 protein eva-1 homolog A

See identical proteins and their annotated locations for NP_001102713.1

Status: PROVISIONAL

Source sequence(s)

CH473957

UniProtKB/TrEMBL

A6IAH4, D4A3V0

Related

ENSRNOP00000009321.5, ENSRNOT00000009321.6

Conserved Domains (1) summary

pfam14851
Location:20 → 159

FAM176; FAM176 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

116151595..116200827

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108150.2 → XP_038964078.1 protein eva-1 homolog A isoform X3

Conserved Domains (1) summary

pfam14851
Location:1 → 98

FAM176; FAM176 family
XM_006236708.5 → XP_006236770.1 protein eva-1 homolog A isoform X1

See identical proteins and their annotated locations for XP_006236770.1

UniProtKB/TrEMBL

A6IAH4, D4A3V0

Conserved Domains (1) summary

pfam14851
Location:20 → 159

FAM176; FAM176 family
XM_039108149.2 → XP_038964077.1 protein eva-1 homolog A isoform X2

Conserved Domains (1) summary

pfam14851
Location:3 → 126

FAM176; FAM176 family