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    Ap3b2 adaptor related protein complex 3 subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308777, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ap3b2provided by RGD
    Official Full Name
    adaptor related protein complex 3 subunit beta 2provided by RGD
    Primary source
    RGD:1308950
    See related
    EnsemblRapid:ENSRNOG00000019249 AllianceGenome:RGD:1308950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Predicted to be active in presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 48. Orthologous to human AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 197.1), Uterus (RPKM 19.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap3b2 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144821819..144854533, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135412580..135445191, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143284041..143315846, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene uncharacterized LOC134483747 Neighboring gene uncharacterized LOC134483748 Neighboring gene uncharacterized LOC102555928 Neighboring gene cDNA sequence BC048679-like Neighboring gene small Cajal body-specific RNA 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. Mössinger J, et al. EMBO Rep, 2012 Dec. PMID 23146885, Free PMC Article
    2. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anterograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterograde synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anterograde synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-3 complex subunit beta-2
    Names
    adaptor-related protein complex 3, beta 2 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107532.2 → NP_001101002.2  AP-3 complex subunit beta-2

      Status: VALIDATED

      Source sequence(s)
      FQ085944, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JCF9
      Related
      ENSRNOP00000107834.1, ENSRNOT00000026030.9
      Conserved Domains (3) summary
      sd00044
      Location:111 → 139
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:34 → 590
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:804 → 947
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144821819..144854533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262715.1 → XP_063118785.1  AP-3 complex subunit beta-2 isoform X3

    2. XM_063262713.1 → XP_063118783.1  AP-3 complex subunit beta-2 isoform X2

    3. XM_063262712.1 → XP_063118782.1  AP-3 complex subunit beta-2 isoform X1

      Related
      ENSRNOP00000098987.1, ENSRNOT00000159502.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.