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    Hook1 hook microtubule-tethering protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313370, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hook1provided by RGD
    Official Full Name
    hook microtubule-tethering protein 1provided by RGD
    Primary source
    RGD:1309987
    See related
    EnsemblRapid:ENSRNOG00000026226 AllianceGenome:RGD:1309987
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytoskeletal protein binding activity; dynein light intermediate chain binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within Golgi organization and manchette assembly. Predicted to be located in microtubule cytoskeleton. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human HOOK1 (hook microtubule tethering protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 221.1), Kidney (RPKM 202.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hook1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (115940199..116003482)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (110824501..110887791)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (114940053..115000691)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene uncharacterized LOC103692418 Neighboring gene uncharacterized LOC120102925 Neighboring gene cytochrome P450 2J3-like Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons. Olenick MA, et al. J Cell Biol, 2019 Jan 7. PMID 30373907, Free PMC Article
    2. The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse. Mendoza-Lujambio I, et al. Hum Mol Genet, 2002 Jul 1. PMID 12075009
    3. Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis. Moreno RD, et al. Dev Biol, 2006 May 1. PMID 16540102
    4. Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway. Luiro K, et al. Hum Mol Genet, 2004 Dec 1. PMID 15471887
    5. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Schumacher JM, et al. Biol Reprod, 1998 Jul. PMID 9674995

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within manchette assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Hook homolog 1
    Names
    hook homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107946.1 → NP_001101416.1  protein Hook homolog 1

      See identical proteins and their annotated locations for NP_001101416.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473998
      UniProtKB/TrEMBL
      A0A8I6AX65, A6JRI4, D3ZB48
      Related
      ENSRNOP00000012396.4, ENSRNOT00000012396.7
      Conserved Domains (2) summary
      pfam05622
      Location:15 → 720
      HOOK; HOOK protein
      cl19219
      Location:502 → 584
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      115940199..116003482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287638.1 → XP_063143708.1  protein Hook homolog 1 isoform X3

      Related
      ENSRNOP00000033736.2, ENSRNOT00000038196.3

    2. XM_039109897.2 → XP_038965825.1  protein Hook homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AX65
      Related
      ENSRNOP00000102757.1, ENSRNOT00000162757.1
      Conserved Domains (2) summary
      pfam05622
      Location:191 → 724
      HOOK; HOOK protein
      cd22225
      Location:27 → 168
      HkD_Hook1; Hook domain found in protein Hook 1 (Hook1) and similar proteins

    3. XM_039109898.2 → XP_038965826.1  protein Hook homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AX65

    4. XM_063287639.1 → XP_063143709.1  protein Hook homolog 1 isoform X4

    RNA

    1. XR_005504438.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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