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    Plekhm3 pleckstrin homology domain containing M3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316455, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plekhm3provided by RGD
    Official Full Name
    pleckstrin homology domain containing M3provided by RGD
    Primary source
    RGD:1307151
    See related
    EnsemblRapid:ENSRNOG00000023760 AllianceGenome:RGD:1307151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dapr; Plekhm1l; RGD1307151
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in myoblast differentiation. Predicted to be located in Golgi apparatus and plasma membrane. Orthologous to human PLEKHM3 (pleckstrin homology domain containing M3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 82.5), Adrenal (RPKM 72.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhm3 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73659998..73819079, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (66166233..66325332, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71492665..71651529, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094695 Neighboring gene cyclin Y-like 1 Neighboring gene basic proline-rich protein-like Neighboring gene frizzled class receptor 5 Neighboring gene uncharacterized LOC120094696 Neighboring gene uncharacterized LOC102552040 Neighboring gene crystallin, gamma E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. Virtanen C, et al. J Biol Chem, 2009 Jan 16. PMID 19028694

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain containing M3; pleckstrin homology domain-containing family M member 3
    Names
    differentiation associated protein
    pleckstrin homology domain containing, family M, member 1-like
    pleckstrin homology domain containing, family M, member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431255.1 → NP_001418184.1  pleckstrin homology domain containing M3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A959

    2. NM_001431256.1 → NP_001418185.1  pleckstrin homology domain containing M3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A959

    3. NM_001431257.1 → NP_001418186.1  pleckstrin homology domain containing M3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A959

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      73659998..73819079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596816.3 → XP_017452305.1  pleckstrin homology domain-containing family M member 3 isoform X1

      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    2. XM_039084591.2 → XP_038940519.1  pleckstrin homology domain-containing family M member 3 isoform X4

      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 653
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    3. XM_017596815.3 → XP_017452304.1  pleckstrin homology domain-containing family M member 3 isoform X1

      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    4. XM_006245080.5 → XP_006245142.1  pleckstrin homology domain-containing family M member 3 isoform X1

      See identical proteins and their annotated locations for XP_006245142.1

      UniProtKB/TrEMBL
      D4A959
      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    5. XM_017596817.3 → XP_017452306.1  pleckstrin homology domain-containing family M member 3 isoform X1

      Related
      ENSRNOP00000103772.1, ENSRNOT00000153205.1
      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    6. XM_017596819.3 → XP_017452308.1  pleckstrin homology domain-containing family M member 3 isoform X1

      UniProtKB/TrEMBL
      D4A959
      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    7. XM_017596820.3 → XP_017452309.1  pleckstrin homology domain-containing family M member 3 isoform X1

      UniProtKB/TrEMBL
      D4A959
      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    8. XM_017596818.3 → XP_017452307.1  pleckstrin homology domain-containing family M member 3 isoform X1

      UniProtKB/TrEMBL
      D4A959
      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 727
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    9. XM_039084592.2 → XP_038940520.1  pleckstrin homology domain-containing family M member 3 isoform X5

      UniProtKB/TrEMBL
      A6IPI7
      Conserved Domains (2) summary
      pfam13901
      Location:255 → 452
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:89 → 176
      PH-like; Pleckstrin homology-like domain

    10. XM_039084593.2 → XP_038940521.1  pleckstrin homology domain-containing family M member 3 isoform X5

      UniProtKB/TrEMBL
      A6IPI7
      Conserved Domains (2) summary
      pfam13901
      Location:255 → 452
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:89 → 176
      PH-like; Pleckstrin homology-like domain

    11. XM_039084589.2 → XP_038940517.1  pleckstrin homology domain-containing family M member 3 isoform X2

      Conserved Domains (3) summary
      cd14674
      Location:215 → 304
      PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
      pfam13901
      Location:530 → 703
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl17171
      Location:364 → 451
      PH-like; Pleckstrin homology-like domain

    12. XM_063267901.1 → XP_063123971.1  pleckstrin homology domain-containing family M member 3 isoform X3

    13. XM_063267902.1 → XP_063123972.1  pleckstrin homology domain-containing family M member 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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