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    Fastkd2 FAST kinase domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fastkd2provided by RGD
    Official Full Name
    FAST kinase domains 2provided by RGD
    Primary source
    RGD:1307883
    See related
    EnsemblRapid:ENSRNOG00000023923 AllianceGenome:RGD:1307883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307883
    Summary
    Predicted to enable rRNA binding activity. Predicted to be involved in several processes, including mitochondrial gene expression; mitochondrial large ribosomal subunit assembly; and post-transcriptional regulation of gene expression. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 44. Orthologous to human FASTKD2 (FAST kinase domains 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 85.8), Muscle (RPKM 68.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fastkd2 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (72659961..72681986)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (65166148..65188184)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (70448386..70471420)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene dystrotelin Neighboring gene malate dehydrogenase 1B Neighboring gene dnaJ homolog subfamily A member 1 pseudogene Neighboring gene uncharacterized LOC108351943 Neighboring gene uncharacterized LOC134480376

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Antonicka H, et al. Cell Rep, 2015 Feb 17. PMID 25683715
    2. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Arroyo JD, et al. Cell Metab, 2016 Dec 13. PMID 27667664, Free PMC Article
    3. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94943

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009673.1 → NP_001009673.1  FAST kinase domain-containing protein 2, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001009673.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088416
      UniProtKB/Swiss-Prot
      Q5M7V7
      Conserved Domains (4) summary
      smart00952
      Location:609 → 665
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:433 → 502
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:551 → 586
      FAST_2; FAST kinase-like protein, subdomain 2
      pfam08689
      Location:356 → 516
      Med5; Mediator complex subunit Med5

    2. NM_001398523.1 → NP_001385452.1  FAST kinase domain-containing protein 2, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0H2UHK3, A6IPH0
      Related
      ENSRNOP00000112158.1, ENSRNOT00000159270.1
      Conserved Domains (3) summary
      smart00952
      Location:619 → 675
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:443 → 512
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:561 → 596
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      72659961..72681986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M7V7.1 GenPept UniProtKB/Swiss-Prot:Q5M7V7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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