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    St6galnac2 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303692, updated on 13-Apr-2024

    Summary

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    Symbol
    St6galnac2provided by RGD
    Full Name
    ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2provided by RGD
    Primary source
    RGD:1560747
    See related
    Ensembl:ENSRNOG00000012083 AllianceGenome:RGD:1560747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat7b
    Summary
    Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in protein O-linked glycosylation and protein sialylation. Predicted to be located in Golgi apparatus. Predicted to be integral component of membrane. Orthologous to human ST6GALNAC2 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 139.8), Heart (RPKM 126.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St6galnac2 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102409048..102427299, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101910220..101928412, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105650866..105668579, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA R38 Neighboring gene uncharacterized LOC108352161 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene matrix remodeling associated 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression system for structural and functional studies of human glycosylation enzymes. Moremen KW, et al. Nat Chem Biol, 2018 Feb. PMID 29251719, Free PMC Article
    2. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. Samyn-Petit B, et al. Biochim Biophys Acta, 2000 Apr 6. PMID 10742600
    3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124782

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Names
    Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    ST6 GalNAc alpha-2,6-sialyltransferase 2
    ST6GALNAC2, alpha-2,6-sialyltransferase 2
    ST6GalNAc II
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase II ()
    sialyltransferase 7B
    NP_001026822.1
    XP_038942127.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031652.2 → NP_001026822.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

      See identical proteins and their annotated locations for NP_001026822.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A9Z9, A6HKY6, F7FDY5, Q6ZYN8
      Related
      ENSRNOP00000016622.4, ENSRNOT00000016622.7
      Conserved Domains (1) summary
      pfam00777
      Location:110 → 372
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102409048..102427299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086199.2 → XP_038942127.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:88 → 291
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version

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