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    Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361632, updated on 14-Nov-2024

    Summary

    Official Symbol
    Pik3c2aprovided by RGD
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alphaprovided by RGD
    Primary source
    RGD:1310389
    See related
    EnsemblRapid:ENSRNOG00000020479 AllianceGenome:RGD:1310389
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable clathrin binding activity and phosphatidylinositol kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and negative regulation of zinc ion transmembrane transport. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 203.7), Lung (RPKM 188.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pik3c2a in Genome Data Viewer
    Location:
    1q35
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (180012248..180117786, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (170577942..170684353, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (185210922..185326314)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A7 Neighboring gene uncharacterized LOC120099912 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene ribosomal protein S13 Neighboring gene CCA tRNA nucleotidyltransferase 1, mitochondrial-like Neighboring gene nucleobindin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphatidylinositol-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
    Names
    phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
    phosphoinositide-3-kinase, class 2, alpha polypeptide
    NP_001101970.1
    XP_038938729.1
    XP_063123573.1
    XP_063123577.1
    XP_063123580.1
    XP_063123582.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108500.1NP_001101970.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

      See identical proteins and their annotated locations for NP_001101970.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6I8E5, D3ZTF6
      Related
      ENSRNOP00000051993.2, ENSRNOT00000055120.4
      Conserved Domains (6) summary
      cd07289
      Location:14271535
      PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:678850
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:15611682
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:8711039
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05176
      Location:10441396
      PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
      pfam00794
      Location:411514
      PI3K_rbd; PI3-kinase family, ras-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      180012248..180117786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267507.1XP_063123577.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    2. XM_063267503.1XP_063123573.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

      UniProtKB/TrEMBL
      A6I8E5, D3ZTF6
    3. XM_063267510.1XP_063123580.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

      UniProtKB/TrEMBL
      A6I8E7
    4. XM_063267512.1XP_063123582.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X4

    5. XM_039082801.2XP_038938729.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X5

      Conserved Domains (4) summary
      cd04012
      Location:678850
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:8711039
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:421514
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl21453
      Location:10441139
      PKc_like; Protein Kinases, catalytic domain