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    Wbp1 WW domain binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297381, updated on 5-Mar-2024

    Summary

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    Symbol
    Wbp1provided by RGD
    Full Name
    WW domain binding protein 1provided by RGD
    Primary source
    RGD:1304961
    See related
    Ensembl:ENSRNOG00000008720 AllianceGenome:RGD:1304961
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable WW domain binding activity. Predicted to be integral component of membrane. Orthologous to human WBP1 (WW domain binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 222.5), Thymus (RPKM 215.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wbp1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117182880..117185279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115625168..115627567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113951873..113954272, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23,pseudogene 8 Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene INO80 complex subunit B Neighboring gene uncharacterized LOC108350719 Neighboring gene rhotekin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Chen HI, et al. Proc Natl Acad Sci U S A, 1995 Aug 15. PMID 7644498, Free PMC Article
    2. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Ludes-Meyers JH, et al. Oncogene, 2004 Jun 24. PMID 15064722, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables WW domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106600.1 → NP_001100070.1  WW domain-binding protein 1

      See identical proteins and their annotated locations for NP_001100070.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      B0BNH9, F7FKT6
      Conserved Domains (1) summary
      pfam11669
      Location:36 → 142
      WBP-1; WW domain-binding protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117182880..117185279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236713.5 → XP_006236775.1  WW domain-binding protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006236775.1

      UniProtKB/TrEMBL
      A0A0G2K8K7
      Related
      ENSRNOP00000074644.2
      Conserved Domains (1) summary
      pfam11669
      Location:70 → 176
      WBP-1; WW domain-binding protein 1

    2. XM_006236712.5 → XP_006236774.1  WW domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006236774.1

      UniProtKB/TrEMBL
      A0A0G2K3J0, A0A0G2K8K7, A6IAK6
      Related
      ENSRNOP00000072657.1
      Conserved Domains (1) summary
      pfam11669
      Location:71 → 177
      WBP-1; WW domain-binding protein 1

    3. XM_063285790.1 → XP_063141860.1  WW domain-binding protein 1 isoform X3

    4. XM_063285791.1 → XP_063141861.1  WW domain-binding protein 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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