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    Hoxb3 homeo box B3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303488, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Hoxb3provided by RGD
    Official Full Name
    homeo box B3provided by RGD
    Primary source
    RGD:1310780
    See related
    EnsemblRapid:ENSRNOG00000008313 AllianceGenome:RGD:1310780
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including angiogenesis; embryonic skeletal system morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; face development; and nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human HOXB3 (homeobox B3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 61.6), Adrenal (RPKM 46.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hoxb3 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81786001..81810655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81258739..81314134)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84170629..84196823)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microRNA 10a Neighboring gene homeo box B4 Neighboring gene uncharacterized LOC102550580 Neighboring gene homeobox B2 Neighboring gene homeo box B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. Guazzi S, et al. J Biol Chem, 1998 May 1. PMID 9556594
    2. Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects. Magnusson M, et al. Exp Hematol, 2007 Sep. PMID 17761289
    3. Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Manley NR, et al. Dev Biol, 1997 Dec 15. PMID 9441667
    4. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. Chung N, et al. Mol Biol Rep, 2009 Feb. PMID 17972163
    5. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Manley NR, et al. Dev Biol, 1998 Mar 1. PMID 9520319

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HOXB3 promotes trophoblast cell proliferation, invasion, and migration to alleviate preeclampsia via mediating the Notch/Wnt/beta-catenin pathway.
      Title: HOXB3 promotes trophoblast cell proliferation, invasion, and migration to alleviate preeclampsia via mediating the Notch/Wnt/β-catenin pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic skeletal system morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within face development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glossopharyngeal nerve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rhombomere development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thyroid gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Hox-B3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107042.1 → NP_001100512.1  homeobox protein Hox-B3

      See identical proteins and their annotated locations for NP_001100512.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81786001..81810655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597314.3 → XP_017452803.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)

    2. XM_017597315.3 → XP_017452804.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)

    3. XM_006247194.5 → XP_006247256.1  homeobox protein Hox-B3 isoform X2

      See identical proteins and their annotated locations for XP_006247256.1

      UniProtKB/TrEMBL
      B2RYQ0, F7FL39
      Related
      ENSRNOP00000011027.5, ENSRNOT00000011027.8
      Conserved Domains (2) summary
      pfam00046
      Location:190 → 243
      Homeobox; Homeobox domain
      pfam13293
      Location:364 → 426
      DUF4074; Domain of unknown function (DUF4074)

    4. XM_039086074.2 → XP_038942002.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)

    5. XM_039086075.2 → XP_038942003.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)
    Nucleotide Protein Strain
    Heading Accession and Version

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