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    Glyctk glycerate kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684314, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Glyctkprovided by RGD
    Official Full Name
    glycerate kinaseprovided by RGD
    Primary source
    RGD:1591498
    See related
    EnsemblRapid:ENSRNOG00000046307 AllianceGenome:RGD:1591498
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables glycerate kinase activity. Predicted to be involved in fructose catabolic process and protein phosphorylation. Is active in cytosol. Human ortholog(s) of this gene implicated in D-glyceric aciduria. Orthologous to human GLYCTK (glycerate kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 488.8), Kidney (RPKM 468.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glyctk in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115676071..115681403, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106795461..106802675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114846210..114853374, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene collagen, type VI, alpha 4 Neighboring gene ribosomal protein L6, pseudogene 10 Neighboring gene microRNA let-7g Neighboring gene WD repeat domain 82 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2. Guo JH, et al. DNA Seq, 2006 Feb. PMID 16753811
    2. Purification of rat liver glycerate kinase and studies of its enzymatic and immunological properties. Katayama H, et al. J Biochem, 1980 Sep. PMID 6252205
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycerate kinase
    NP_001102919.1
    XP_006243918.1
    XP_006243919.1
    XP_038938080.1
    XP_038938083.1
    XP_063122211.1
    XP_063122212.1
    XP_063122213.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109449.2 → NP_001102919.1  glycerate kinase

      See identical proteins and their annotated locations for NP_001102919.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105621
      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Related
      ENSRNOP00000064339.2, ENSRNOT00000074595.3
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115676071..115681403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266142.1 → XP_063122212.1  glycerate kinase isoform X2

    2. XM_006243857.5 → XP_006243919.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_006243919.1

      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    3. XM_063266143.1 → XP_063122213.1  glycerate kinase isoform X2

    4. XM_039082152.2 → XP_038938080.1  glycerate kinase isoform X1

      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    5. XM_006243856.5 → XP_006243918.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_006243918.1

      UniProtKB/Swiss-Prot
      Q0VGK3
      UniProtKB/TrEMBL
      A6I2P3
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    6. XM_063266141.1 → XP_063122211.1  glycerate kinase isoform X2

    7. XM_039082155.2 → XP_038938083.1  glycerate kinase isoform X3

      Conserved Domains (1) summary
      COG2379
      Location:4 → 388
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VGK3.1 GenPept UniProtKB/Swiss-Prot:Q0VGK3

    Gene LinkOut

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