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    Etv6 ETS variant transcription factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312777, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Etv6provided by RGD
    Official Full Name
    ETS variant transcription factor 6provided by RGD
    Primary source
    RGD:1559537
    See related
    EnsemblRapid:ENSRNOG00000064991 AllianceGenome:RGD:1559537
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Predicted to be involved in cell differentiation; hematopoietic stem cell proliferation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including mesenchymal cell apoptotic process; regulation of transcription, DNA-templated; and vitellogenesis. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and thrombocytopenia. Orthologous to human ETV6 (ETS variant transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 90.4), Thymus (RPKM 78.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Etv6 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (168580405..168819817)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (166849031..167085211)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (167754684..167992370)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2, pseudogene 2 Neighboring gene esterase D, pseudogene 2 Neighboring gene keratin-associated protein 5-5-like Neighboring gene uncharacterized LOC120102413 Neighboring gene uncharacterized LOC134486853 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Bcl2-like 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of new translocations involving ETV6 in hematologic malignancies by fluorescence in situ hybridization and spectral karyotyping. Odero MD, et al. Genes Chromosomes Cancer, 2001 Jun. PMID 11319801
    2. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Zhang MY, et al. Nat Genet, 2015 Feb. PMID 25581430, Free PMC Article
    3. [Analysis and clinical significance of ETV6 rearrangement in myelodysplastic syndromes patients]. Ding BT, et al. Zhonghua Xue Ye Xue Za Zhi, 2007 Dec. PMID 18476590
    4. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. Apperley JF, et al. N Engl J Med, 2002 Aug 15. PMID 12181402
    5. Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia. La Starza R, et al. Haematologica, 2002 Aug. PMID 12161353

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124677

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mesenchymal cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vitellogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor ETV6
    Names
    ets variant gene 6 (TEL oncogene)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037353.1 → NP_001032430.1  transcription factor ETV6

      See identical proteins and their annotated locations for NP_001032430.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105773
      UniProtKB/TrEMBL
      F7FKU1, Q3KRD1
      Related
      ENSRNOP00000110530.1, ENSRNOT00000148801.1
      Conserved Domains (2) summary
      cd08535
      Location:56 → 123
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      smart00413
      Location:339 → 425
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      168580405..168819817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107692.2 → XP_038963620.1  transcription factor ETV6 isoform X1

      UniProtKB/TrEMBL
      F7FKU1
      Related
      ENSRNOP00000007889.6, ENSRNOT00000007889.7
      Conserved Domains (2) summary
      cd08535
      Location:67 → 134
      SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
      smart00413
      Location:350 → 436
      ETS; erythroblast transformation specific domain

    2. XM_039107693.2 → XP_038963621.1  transcription factor ETV6 isoform X2

      Conserved Domains (1) summary
      smart00413
      Location:131 → 217
      ETS; erythroblast transformation specific domain
    Nucleotide Protein Strain
    Heading Accession and Version

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