Polk DNA polymerase kappa [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Polkprovided by RGD
Official Full Name: DNA polymerase kappaprovided by RGD
Primary source: RGD:620058
See related: EnsemblRapid:ENSRNOG00000060626 AllianceGenome:RGD:620058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dinb1
Summary: Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in cellular response to UV; error-prone translesion synthesis; and nucleotide-excision repair, DNA gap filling. Predicted to act upstream of or within DNA repair. Predicted to be located in nuclear body. Predicted to be active in nucleus. Predicted to colocalize with site of DNA damage. Orthologous to human POLK (DNA polymerase kappa). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 54.9), Lung (RPKM 38.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (29556831..29616960, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (27822228..27882331, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (27305718..27364906, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BG372536 (e-PCR)
- UniSTS:248926

BE101594 (e-PCR)
- UniSTS:243621

D2Uwm16 (e-PCR)
- UniSTS:240115

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in error-prone translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in error-prone translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-excision repair, DNA gap filling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA polymerase kappa

Names: DNA-directed DNA polymerase kappa; polymerase (DNA directed) kappa; polymerase (DNA) kappa

XP_038957600.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433859.1 → NP_001420788.1 DNA polymerase kappa

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002
NM_138516.2 → NP_612525.2 DNA polymerase kappa

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

Related

ENSRNOP00000073092.2, ENSRNOT00000078639.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

29556831..29616960 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101672.2 → XP_038957600.1 DNA polymerase kappa isoform X1

UniProtKB/TrEMBL

A0A0G2JY51, A0A0G2K4L7, A6I508

Conserved Domains (2) summary

smart00734
Location:760 → 786

ZnF_Rad18; Rad18-like CCHC zinc finger

cd03586
Location:103 → 513

PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa