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    Ddx19b DEAD-box helicase 19B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690693, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ddx19bprovided by RGD
    Official Full Name
    DEAD-box helicase 19Bprovided by RGD
    Primary source
    RGD:1593382
    See related
    Ensembl:ENSRNOG00000064019 AllianceGenome:RGD:1593382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zd10a
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in nuclear envelope. Predicted to be active in cytoplasmic stress granule and nucleus. Orthologous to several human genes including DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 186.1), Thymus (RPKM 121.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddx19b in Genome Data Viewer
    Location:
    19q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55877567..55910134, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38968215..38998907, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43217199..43246196)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene DEAD-box helicase 19A Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene transfer RNA glycine (anticodon GCC) 11 Neighboring gene heterogeneous nuclear ribonucleoprotein C like 1 Neighboring gene exosome component 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats. Ishii H, et al. Oncogene, 2004 Oct 21. PMID 15361827
    2. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ, et al. Trends Cell Biol, 2013 Aug. PMID 23583578, Free PMC Article
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX19B
    Names
    DEAD (Asp-Glu-Ala-As) box polypeptide 19B
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
    zinc responsive protein ZD10B
    zinc responsive protein Zd10A
    NP_001005895.3
    XP_008770756.1
    XP_038953928.1
    XP_063134361.1
    XP_063134362.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005895.4 → NP_001005895.3  ATP-dependent RNA helicase DDX19B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      Q5XLP8
      Related
      ENSRNOP00000069097.2, ENSRNOT00000084462.2
      Conserved Domains (2) summary
      cd18787
      Location:307 → 443
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cl28899
      Location:75 → 303
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55877567..55910134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278292.1 → XP_063134362.1  ATP-dependent RNA helicase DDX19B isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY21

    2. XM_039098000.2 → XP_038953928.1  ATP-dependent RNA helicase DDX19B isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY21
      Conserved Domains (2) summary
      cd18787
      Location:198 → 334
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cl28899
      Location:1 → 187
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    3. XM_008772534.3 → XP_008770756.1  ATP-dependent RNA helicase DDX19B isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADW1, A0A8I6GAE6
      Related
      ENSRNOP00000083150.1
      Conserved Domains (3) summary
      PTZ00424
      Location:104 → 482
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:320 → 455
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:107 → 309
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    4. XM_063278291.1 → XP_063134361.1  ATP-dependent RNA helicase DDX19B isoform X2

      UniProtKB/TrEMBL
      A0A0G2JY21
    Nucleotide Protein Strain
    Heading Accession and Version

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