Mettl13 methyltransferase 13, eEF1A N-terminus and K55 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl13provided by RGD
Official Full Name: methyltransferase 13, eEF1A N-terminus and K55provided by RGD
Primary source: RGD:1311526
See related: EnsemblRapid:ENSRNOG00000003042 AllianceGenome:RGD:1311526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eef1aknmt; RGD1311526
Summary: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; mitochondrion; and nucleus. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 52.4), Thymus (RPKM 52.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (77419393..77433228, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (74886151..74899937, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (80427595..80441353, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131107 (e-PCR)
- UniSTS:214390

RH140936 (e-PCR)
- UniSTS:222942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eEF1A lysine and N-terminal methyltransferase

Names: methyltransferase 13, eEF1A lysine and N-terminal methyltransferase; methyltransferase like 13; methyltransferase-like protein 13

NP_001127973.1

EC 2.1.1.-

XP_006250214.1

EC 2.1.1.-

XP_038946413.1

EC 2.1.1.-

XP_038946414.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134501.2 → NP_001127973.1 eEF1A lysine and N-terminal methyltransferase isoform 1

See identical proteins and their annotated locations for NP_001127973.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I5ZV13, A6ID93

Related

ENSRNOP00000082496.1, ENSRNOT00000063902.4

Conserved Domains (3) summary

COG0500
Location:507 → 656

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08241
Location:53 → 158

Methyltransf_11; Methyltransferase domain

cl17173
Location:506 → 679

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001434085.1 → NP_001421014.1 eEF1A lysine and N-terminal methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001434086.1 → NP_001421015.1 eEF1A lysine and N-terminal methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

77419393..77433228 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090485.2 → XP_038946413.1 eEF1A lysine and N-terminal methyltransferase isoform X1

Conserved Domains (2) summary

pfam13649
Location:52 → 154

Methyltransf_25; Methyltransferase domain

cl17173
Location:500 → 673

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006250152.5 → XP_006250214.1 eEF1A lysine and N-terminal methyltransferase isoform X1

Conserved Domains (2) summary

pfam13649
Location:52 → 154

Methyltransf_25; Methyltransferase domain

cl17173
Location:500 → 673

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039090486.1 → XP_038946414.1 eEF1A lysine and N-terminal methyltransferase isoform X2

Conserved Domains (1) summary

cl17173
Location:183 → 356

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...