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    Mid2 midline 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363502, updated on 14-Nov-2024

    Summary

    Official Symbol
    Mid2provided by RGD
    Official Full Name
    midline 2provided by RGD
    Primary source
    RGD:1565674
    See related
    EnsemblRapid:ENSRNOG00000060542 AllianceGenome:RGD:1565674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565674
    Summary
    Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in several processes, including defense response to symbiont; negative regulation of viral transcription; and positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytoplasm. Predicted to colocalize with microtubule. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 101. Orthologous to human MID2 (midline 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 111.1), Adrenal (RPKM 61.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mid2 in Genome Data Viewer
    Location:
    Xq33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (109143057..109245257)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (104354692..104456757)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (112019897..112121980)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene TSC22 domain family, member 3 Neighboring gene ribosomal protein L23a, pseudogene 9 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC103694504 Neighboring gene ribosomal protein SA, pseudogene 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase MID2
    NP_001178818.1
    XP_006234309.1
    XP_006234310.1
    XP_063136223.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191889.2NP_001178818.1  probable E3 ubiquitin-protein ligase MID2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JWJ3
      Related
      ENSRNOP00000069903.2, ENSRNOT00000079841.3
      Conserved Domains (5) summary
      smart00502
      Location:239364
      BBC; B-Box C-terminal domain
      smart00336
      Location:195232
      BBOX; B-Box-type zinc finger
      cd00063
      Location:401531
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:2983
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd13739
      Location:536705
      SPRY_PRY_TRIM1; PRY/SPRY domain of tripartite motif-binding protein 1 (TRIM1) or MID2
    2. NM_001434288.1NP_001421217.1  probable E3 ubiquitin-protein ligase MID2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    3. NM_001434289.1NP_001421218.1  probable E3 ubiquitin-protein ligase MID2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    4. NM_001434290.1NP_001421219.1  probable E3 ubiquitin-protein ligase MID2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      109143057..109245257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280153.1XP_063136223.1  probable E3 ubiquitin-protein ligase MID2 isoform X2

      Related
      ENSRNOP00000101518.1, ENSRNOT00000118902.2
    2. XM_006234248.5XP_006234310.1  probable E3 ubiquitin-protein ligase MID2 isoform X3

      Conserved Domains (5) summary
      smart00502
      Location:219344
      BBC; B-Box C-terminal domain
      smart00336
      Location:175212
      BBOX; B-Box-type zinc finger
      cd00063
      Location:381511
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:963
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd13739
      Location:516685
      SPRY_PRY_TRIM1; PRY/SPRY domain of tripartite motif-binding protein 1 (TRIM1) or MID2
    3. XM_006234247.5XP_006234309.1  probable E3 ubiquitin-protein ligase MID2 isoform X1

      UniProtKB/TrEMBL
      A6HLR4
      Conserved Domains (5) summary
      smart00502
      Location:239364
      BBC; B-Box C-terminal domain
      smart00336
      Location:195232
      BBOX; B-Box-type zinc finger
      cd00063
      Location:401501
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00162
      Location:2983
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd13739
      Location:506675
      SPRY_PRY_TRIM1; PRY/SPRY domain of tripartite motif-binding protein 1 (TRIM1) or MID2