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    Dvl2 dishevelled segment polarity protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303251, updated on 10-Jul-2024

    Summary

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    Gene symbol
    Dvl2
    Gene description
    dishevelled segment polarity protein 2
    See related
    EnsemblRapid:ENSRNOG00000017915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dvl-2
    Expression
    Biased expression in Thymus (RPKM 78.4), Lung (RPKM 61.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dvl2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55222245..55231506)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54723356..54732823)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56609810..56619269)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein Neighboring gene PHD finger protein 23 Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression. Cao Y, et al. Eur Rev Med Pharmacol Sci, 2021 Jan. PMID 33577018
    2. Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-κB pathway. Liu XZ, et al. Oncotarget, 2017 Feb 21. PMID 28187436, Free PMC Article
    3. Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Kordes C, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18158920
    4. Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. González-Sancho JM, et al. J Biol Chem, 2013 Mar 29. PMID 23396967, Free PMC Article
    5. The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy. Ma B, et al. J Biol Chem, 2015 May 8. PMID 25825496, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression.
      Title: MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression.
    2. Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
      Title: Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-κB pathway.
    3. Dpr1 promotes the ubiquitination of Dvl2 by pVHL and mediates the protein aggregate-elicited autophagy initiation
      Title: The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.
    4. Wnt-induced dishevelled 2 phosphorylation has effects in in canonical and noncanonical Wnt3a and Wnt5a signaling
      Title: Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    segment polarity protein dishevelled homolog DVL-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172056.1 → NP_001165527.1  segment polarity protein dishevelled homolog DVL-2

      See identical proteins and their annotated locations for NP_001165527.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HG06, D3ZB71
      Related
      ENSRNOP00000024348.5, ENSRNOT00000024348.8
      Conserved Domains (5) summary
      smart00021
      Location:13 → 93
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:265 → 352
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:424 → 507
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:123 → 263
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:515 → 726
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55222245..55231506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246715.5 → XP_006246777.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

      Conserved Domains (5) summary
      smart00021
      Location:13 → 93
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:261 → 348
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:420 → 503
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:123 → 259
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:511 → 722
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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