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    Sgce sarcoglycan, epsilon [ Rattus norvegicus (Norway rat) ]

    Gene ID: 432360, updated on 6-Jun-2024

    Summary

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    Symbol
    Sgceprovided by RGD
    Full Name
    sarcoglycan, epsilonprovided by RGD
    Primary source
    RGD:1303201
    See related
    Ensembl:ENSRNOG00000046905 AllianceGenome:RGD:1303201
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in brain development; kidney development; and skeletal muscle tissue development. Predicted to be located in Golgi apparatus and dendrite membrane. Predicted to be part of sarcoglycan complex. Human ortholog(s) of this gene implicated in myoclonic dystonia. Orthologous to human SGCE (sarcoglycan epsilon). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 150.6), Heart (RPKM 119.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgce in Genome Data Viewer
    Location:
    4q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (33738066..33808907, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (32771477..32842238, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (29726140..29769902, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552043 Neighboring gene CAS1 domain containing 1 Neighboring gene paternally expressed 10 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, developmental regulation and neural localization of rat epsilon-sarcoglycan. Xiao J, et al. Brain Res Mol Brain Res, 2003 Nov 26. PMID 14625080
    2. Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex. Vermiglio G, et al. Ital J Anat Embryol, 2012. PMID 22894000
    3. SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA. Esapa CT, et al. Hum Mol Genet, 2007 Feb 1. PMID 17200151
    4. Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation. Sharma P, et al. Am J Physiol Lung Cell Mol Physiol, 2008 Jan. PMID 17993586
    5. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, et al. J Cancer Res Clin Oncol, 2017 Apr. PMID 28035468

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In cerebellar neurons and glial cells alpha-, beta-, gamma-, delta-, and epsilon-sarcoglycans are all expressed.
      Title: Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in kidney development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of dystrophin-associated glycoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sarcoglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epsilon-sarcoglycan
    Names
    epsilon-SG

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002023.2 → NP_001002023.1  epsilon-sarcoglycan

      See identical proteins and their annotated locations for NP_001002023.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089947
      UniProtKB/Swiss-Prot
      Q6YAT4
      UniProtKB/TrEMBL
      A0A8I6GCG9
      Related
      ENSRNOP00000085107.1, ENSRNOT00000119838.1
      Conserved Domains (1) summary
      pfam05510
      Location:34 → 419
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      33738066..33808907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107995.2 → XP_038963923.1  epsilon-sarcoglycan isoform X5

      UniProtKB/TrEMBL
      A0A8I6GCG9
      Conserved Domains (1) summary
      pfam05510
      Location:34 → 410
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    2. XM_063286431.1 → XP_063142501.1  epsilon-sarcoglycan isoform X11

      UniProtKB/TrEMBL
      A0A8I6GCG9

    3. XM_039107994.2 → XP_038963922.1  epsilon-sarcoglycan isoform X4

      UniProtKB/TrEMBL
      A0A8I6AA37, A0A8I6GCG9
      Related
      ENSRNOP00000089367.1
      Conserved Domains (1) summary
      pfam05510
      Location:34 → 419
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    4. XM_039107993.2 → XP_038963921.1  epsilon-sarcoglycan isoform X8

      UniProtKB/TrEMBL
      A0A8I6AGU2, A0A8I6GCG9
      Related
      ENSRNOP00000091800.1
      Conserved Domains (1) summary
      pfam05510
      Location:79 → 446
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    5. XM_039107992.2 → XP_038963920.1  epsilon-sarcoglycan isoform X6

      UniProtKB/TrEMBL
      A0A8I6GCG9, M0R4Y0
      Related
      ENSRNOP00000064432.3
      Conserved Domains (1) summary
      pfam05510
      Location:79 → 455
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    6. XM_039107998.2 → XP_038963926.1  epsilon-sarcoglycan isoform X10

      UniProtKB/TrEMBL
      A0A8I6GCG9
      Conserved Domains (1) summary
      pfam05510
      Location:33 → 369
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    7. XM_039107997.2 → XP_038963925.1  epsilon-sarcoglycan isoform X9

      UniProtKB/TrEMBL
      A0A8I6GCG9
      Related
      ENSRNOP00000094451.1
      Conserved Domains (1) summary
      pfam05510
      Location:33 → 378
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    8. XM_039107990.2 → XP_038963918.1  epsilon-sarcoglycan isoform X2

      UniProtKB/TrEMBL
      A0A8I6GCG9
      Conserved Domains (1) summary
      pfam05510
      Location:79 → 446
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    9. XM_039107988.2 → XP_038963916.1  epsilon-sarcoglycan isoform X1

      UniProtKB/TrEMBL
      A0A8I6GCG9
      Conserved Domains (1) summary
      pfam05510
      Location:79 → 455
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    10. XM_063286433.1 → XP_063142503.1  epsilon-sarcoglycan isoform X13

      UniProtKB/TrEMBL
      A0A8I6GCG9

    11. XM_063286432.1 → XP_063142502.1  epsilon-sarcoglycan isoform X12

      UniProtKB/TrEMBL
      A0A8I6AKU0, A0A8I6GCG9

    12. XM_063286430.1 → XP_063142500.1  epsilon-sarcoglycan isoform X7

      UniProtKB/TrEMBL
      A0A8I6GCG9

    13. XM_039107991.2 → XP_038963919.1  epsilon-sarcoglycan isoform X3

      UniProtKB/TrEMBL
      A0A8I6GCG9
      Conserved Domains (1) summary
      pfam05510
      Location:79 → 455
      Sarcoglycan_2; Sarcoglycan alpha/epsilon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6YAT4.1 GenPept UniProtKB/Swiss-Prot:Q6YAT4

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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