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    Rerg RAS-like, estrogen-regulated, growth-inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502916, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Rergprovided by RGD
    Official Full Name
    RAS-like, estrogen-regulated, growth-inhibitorprovided by RGD
    Primary source
    RGD:1562829
    See related
    Ensembl:ENSRNOG00000027592 AllianceGenome:RGD:1562829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562829
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in several processes, including Ras protein signal transduction; negative regulation of cell growth; and negative regulation of cell population proliferation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human RERG (RAS like estrogen regulated growth inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 147.6), Lung (RPKM 77.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rerg in Genome Data Viewer
    Location:
    4q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171712794..171821268, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169981634..170089777, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (171069161..171176678, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene ubiquitin-like Neighboring gene uncharacterized LOC120102419 Neighboring gene uncharacterized LOC134486652 Neighboring gene uncharacterized LOC134486857 Neighboring gene prohibitin 1, pseudogene 5 Neighboring gene protein tyrosine phosphatase, receptor type, O Neighboring gene uncharacterized LOC120102421

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. Finlin BS, et al. J Biol Chem, 2001 Nov 9. PMID 11533059
    2. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related and estrogen-regulated growth inhibitor
    NP_001385858.1
    XP_006237644.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398929.1 → NP_001385858.1  ras-related and estrogen-regulated growth inhibitor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IMK1, F1M2G3
      Related
      ENSRNOP00000028930.3, ENSRNOT00000030850.5
      Conserved Domains (1) summary
      cd04146
      Location:8 → 169
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      171712794..171821268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237582.4 → XP_006237644.1  ras-related and estrogen-regulated growth inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006237644.1

      UniProtKB/TrEMBL
      A0A8I5ZRS4, A6IMK1, F1M2G3
      Conserved Domains (1) summary
      cd04146
      Location:8 → 169
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
    Nucleotide Protein Strain
    Heading Accession and Version

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