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    Sh3tc1 SH3 domain and tetratricopeptide repeats 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305441, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sh3tc1provided by RGD
    Official Full Name
    SH3 domain and tetratricopeptide repeats 1provided by RGD
    Primary source
    RGD:1305610
    See related
    EnsemblRapid:ENSRNOG00000007993 AllianceGenome:RGD:1305610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Orthologous to human SH3TC1 (SH3 domain and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 133.2), Lung (RPKM 86.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3tc1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79230322..79274622)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75005691..75050001)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80184814..80229207)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481855 Neighboring gene actin binding LIM protein family, member 2 Neighboring gene HtrA serine peptidase 3 Neighboring gene acyl-CoA oxidase 3, pristanoyl Neighboring gene tRNA methyltransferase 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy. Senderek J, et al. Am J Hum Genet, 2003 Nov. PMID 14574644, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    SH3 domain and tetratricopeptide repeat-containing protein 1
    Names
    SH3 domain and tetratricopeptide repeats-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107226.1 → NP_001100696.1  SH3 domain and tetratricopeptide repeat-containing protein 1

      See identical proteins and their annotated locations for NP_001100696.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A6IJZ0, D3ZLQ9
      Conserved Domains (3) summary
      sd00006
      Location:1162 → 1189
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1161 → 1233
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79230322..79274622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251127.5 → XP_006251189.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006251189.1

      UniProtKB/TrEMBL
      A6IJZ0, D3ZLQ9
      Conserved Domains (3) summary
      sd00006
      Location:1162 → 1189
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1161 → 1233
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    2. XM_006251126.5 → XP_006251188.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006251188.1

      UniProtKB/TrEMBL
      A6IJZ0, D3ZLQ9
      Related
      ENSRNOP00000103629.1, ENSRNOT00000135792.1
      Conserved Domains (3) summary
      sd00006
      Location:1162 → 1189
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1161 → 1233
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    3. XM_063273148.1 → XP_063129218.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6IJZ0

    4. XM_063273150.1 → XP_063129220.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZL28

    5. XM_063273149.1 → XP_063129219.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZL28

    6. XM_006251128.5 → XP_006251190.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006251190.1

      UniProtKB/TrEMBL
      A6IJZ0, D3ZLQ9
      Conserved Domains (3) summary
      sd00006
      Location:1162 → 1189
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1161 → 1233
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    7. XM_039091961.2 → XP_038947889.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X4

      Conserved Domains (3) summary
      sd00006
      Location:605 → 655
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:672 → 733
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    8. XM_006251130.5 → XP_006251192.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZL28, D3ZLQ9
      Related
      ENSRNOP00000078567.1, ENSRNOT00000117836.2
      Conserved Domains (3) summary
      sd00006
      Location:1137 → 1164
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1136 → 1208
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:287 → 341
      SH3; Src Homology 3 domain superfamily

    9. XM_006251125.5 → XP_006251187.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006251187.1

      UniProtKB/TrEMBL
      A6IJZ0, D3ZLQ9
      Conserved Domains (3) summary
      sd00006
      Location:1162 → 1189
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1161 → 1233
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:312 → 366
      SH3; Src Homology 3 domain superfamily

    10. XM_039091959.2 → XP_038947887.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      D3ZLQ9
      Conserved Domains (3) summary
      sd00006
      Location:1095 → 1122
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1098 → 1166
      TPR_12; Tetratricopeptide repeat
      cl17036
      Location:245 → 299
      SH3; Src Homology 3 domain superfamily

    11. XM_039091962.2 → XP_038947890.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X5

      Conserved Domains (2) summary
      sd00006
      Location:813 → 840
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:816 → 884
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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