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    Nom1 nucleolar protein with MIF4G domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682058, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nom1provided by RGD
    Official Full Name
    nucleolar protein with MIF4G domain 1provided by RGD
    Primary source
    RGD:1588109
    See related
    EnsemblRapid:ENSRNOG00000048969 AllianceGenome:RGD:1588109
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to act upstream of or within hair follicle maturation. Predicted to be located in nucleolus. Orthologous to human NOM1 (nucleolar protein with MIF4G domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 132.0), Adrenal (RPKM 130.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nom1 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (6562931..6586093, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (5891220..5910741, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (2340034..2356427)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486703 Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene motor neuron and pancreas homeobox 1 Neighboring gene ribosomal L24 domain containing 1, pseudogene 1 Neighboring gene limb development membrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. Simmons HM, et al. Gene, 2005 Feb 28. PMID 15715967
    2. NOM1 targets protein phosphatase I to the nucleolus. Gunawardena SR, et al. J Biol Chem, 2008 Jan 4. PMID 17965019
    3. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hair follicle maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar MIF4G domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      6562931..6586093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108548.2 → XP_038964476.1  nucleolar MIF4G domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUC8, A6KJM4
      Related
      ENSRNOP00000097421.1, ENSRNOT00000100683.2
      Conserved Domains (3) summary
      smart00543
      Location:344 → 540
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      PRK00708
      Location:91 → 166
      PRK00708; twin-arginine translocase subunit TatB
      cl02653
      Location:635 → 741
      MA3; MA3 domain

    2. XM_039108550.2 → XP_038964478.1  nucleolar MIF4G domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      cl02652
      Location:3 → 183
      MIF4G; MIF4G domain
      cl02653
      Location:278 → 384
      MA3; MA3 domain

    3. XM_039108549.2 → XP_038964477.1  nucleolar MIF4G domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6KJM4
      Conserved Domains (2) summary
      smart00543
      Location:344 → 540
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      PRK00708
      Location:91 → 166
      PRK00708; twin-arginine translocase subunit TatB

    4. XM_063286892.1 → XP_063142962.1  nucleolar MIF4G domain-containing protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials