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    ABLIM1 actin binding LIM protein 1 [ Homo sapiens (human) ]

    Gene ID: 3983, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ABLIM1provided by HGNC
    Official Full Name
    actin binding LIM protein 1provided by HGNC
    Primary source
    HGNC:HGNC:78
    See related
    Ensembl:ENSG00000099204 MIM:602330; AllianceGenome:HGNC:78
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABLIM; LIMAB1; LIMATIN; abLIM-1
    Summary
    This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 50.7), heart (RPKM 50.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ABLIM1 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114431110..114801373, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115325183..115686686, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116190869..116528063, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116079781-116080980 Neighboring gene uncharacterized LOC105378494 Neighboring gene actin filament associated protein 1 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:116088199-116088844 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116097011-116098210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116110152-116111044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116164296-116164796 Neighboring gene RNA, 7SL, cytoplasmic 384, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116219699-116220200 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:116247470-116248669 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:116249579-116250078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4083 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:116259001-116260200 Neighboring gene Sharpr-MPRA regulatory region 9264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116278667-116279186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4088 Neighboring gene Sharpr-MPRA regulatory region 11198 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:116471523-116472022 Neighboring gene peptidylprolyl isomerase A pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116514326-116514855 Neighboring gene uncharacterized LOC101927692 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2847 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:116581943-116582443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4092 Neighboring gene TATA-box binding protein associated factor 9b pseudogene 2 Neighboring gene FHF complex subunit HOOK interacting protein 2A Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:116640543-116641171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker. Liu D, et al. Dis Markers, 2022. PMID 36583064, Free PMC Article
    2. Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report with review of the literature. Sibira R, et al. Diagn Pathol, 2024 Oct 3. PMID 39363234, Free PMC Article
    3. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma. Dong X, et al. Int J Biol Sci, 2020. PMID 33061800, Free PMC Article
    4. Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. Wang KS, et al. J Mol Neurosci, 2012 Feb. PMID 21547531
    5. ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling. He Y, et al. Cell Death Differ, 2024 Feb. PMID 38228802, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report with review of the literature.
      Title: Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report with review of the literature.
    2. ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IkBalpha ubiquitination and activating NF-kB signaling.
      Title: ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
    3. Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker.
      Title: Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker.
    4. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
      Title: Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
    5. Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.
      Title: Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.
    6. Exon 11 inclusion isoform of ABLIM1 may have a muscle-specific function, and its abnormal splicing could be related to muscle symptoms of myotonic dystrophy type 1.
      Title: ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1.
    7. SNP rs727532 in ABLIM1 (10q25) had significant association in the multivariate test & strong associations with novelty seeking, harm avoidance, reward dependence and alcohol dependence in the COGA sample.
      Title: Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide searching of rare genetic variants in WTCCC data.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1224, FLJ14564, KIAA0059, DKFZp781D0148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin-binding LIM protein 1
    Names
    actin-binding LIM protein family member 1
    actin-binding double-zinc-finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029872.2 RefSeqGene

      Range
      168369..395532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003407.2 → NP_001003407.1  actin-binding LIM protein 1 isoform b

      See identical proteins and their annotated locations for NP_001003407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (b) contains a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AL133384, AL354873, AW627433, D31883
      Consensus CDS
      CCDS31288.1
      UniProtKB/TrEMBL
      F8W8M4
      Related
      ENSP00000376682.4, ENST00000392955.8
      Conserved Domains (7) summary
      smart00153
      Location:683 → 718
      VHP; Villin headpiece domain
      cd09327
      Location:39 → 90
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95 → 150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166 → 217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225 → 280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:290 → 682
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:520 → 580
      Rifin_STEVOR; Rifin/stevor family

    2. NM_001322882.2 → NP_001309811.1  actin-binding LIM protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (d) has a shorter, distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK122891, AL133384, AL354873
      Consensus CDS
      CCDS81509.1
      UniProtKB/TrEMBL
      F8W8M4
      Related
      ENSP00000358260.3, ENST00000369256.6
      Conserved Domains (7) summary
      smart00153
      Location:713 → 748
      VHP; Villin headpiece domain
      cd09327
      Location:39 → 90
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95 → 150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166 → 217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225 → 280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:318 → 712
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:550 → 610
      Rifin_STEVOR; Rifin/stevor family

    3. NM_001322883.2 → NP_001309812.1  actin-binding LIM protein 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL354873
      UniProtKB/TrEMBL
      F8W8M4

    4. NM_001322884.3 → NP_001309813.1  actin-binding LIM protein 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL137025, AL354873
      UniProtKB/TrEMBL
      F8W8M4

    5. NM_001322885.3 → NP_001309814.1  actin-binding LIM protein 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL137025, AL354873
      UniProtKB/TrEMBL
      F8W8M4

    6. NM_001322886.3 → NP_001309815.1  actin-binding LIM protein 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL137025, AL354873
      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:619 → 654
      VHP; Villin headpiece domain
      cd09327
      Location:22 → 73
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:78 → 133
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:149 → 200
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:208 → 263
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:272 → 617
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    7. NM_001322887.2 → NP_001309816.1  actin-binding LIM protein 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL354873
      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (7) summary
      smart00153
      Location:601 → 636
      VHP; Villin headpiece domain
      cd09327
      Location:39 → 90
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95 → 150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166 → 217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225 → 280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:289 → 599
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:400 → 498
      RIFIN; Rifin

    8. NM_001322888.2 → NP_001309817.1  actin-binding LIM protein 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL133384
      Conserved Domains (3) summary
      smart00153
      Location:420 → 455
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 418
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    9. NM_001322889.2 → NP_001309818.1  actin-binding LIM protein 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL133384

    10. NM_001322890.2 → NP_001309819.1  actin-binding LIM protein 1 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) and variant 14 both encode isoform l.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:394 → 429
      VHP; Villin headpiece domain
      pfam16182
      Location:34 → 393
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:231 → 291
      Rifin_STEVOR; Rifin/stevor family

    11. NM_001322891.2 → NP_001309820.1  actin-binding LIM protein 1 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) and variant 13 both encode isoform l.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:394 → 429
      VHP; Villin headpiece domain
      pfam16182
      Location:34 → 393
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:231 → 291
      Rifin_STEVOR; Rifin/stevor family

    12. NM_001322892.2 → NP_001309821.1  actin-binding LIM protein 1 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) and variant 16 both encode isoform n.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:392 → 427
      VHP; Villin headpiece domain
      pfam16182
      Location:34 → 391
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:229 → 289
      Rifin_STEVOR; Rifin/stevor family

    13. NM_001322893.2 → NP_001309822.1  actin-binding LIM protein 1 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) and variant 15 both encode isoform n.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:392 → 427
      VHP; Villin headpiece domain
      pfam16182
      Location:34 → 391
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:229 → 289
      Rifin_STEVOR; Rifin/stevor family

    14. NM_001322894.2 → NP_001309823.1  actin-binding LIM protein 1 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) and variant 18 both encode isoform o.
      Source sequence(s)
      AL133384
      Conserved Domains (3) summary
      smart00153
      Location:380 → 415
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 378
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    15. NM_001322895.2 → NP_001309824.1  actin-binding LIM protein 1 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) and variant 17 both encode isoform o.
      Source sequence(s)
      AL133384
      Conserved Domains (3) summary
      smart00153
      Location:380 → 415
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 378
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    16. NM_001322896.2 → NP_001309825.1  actin-binding LIM protein 1 isoform p

      Status: REVIEWED

      Source sequence(s)
      AL133384, BC002448
      Consensus CDS
      CCDS81508.1
      UniProtKB/Swiss-Prot
      O14639
      Related
      ENSP00000358257.2, ENST00000369253.6
      Conserved Domains (2) summary
      smart00153
      Location:366 → 401
      VHP; Villin headpiece domain
      pfam16182
      Location:8 → 365
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    17. NM_001322897.2 → NP_001309826.1  actin-binding LIM protein 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AL133384
      Conserved Domains (2) summary
      smart00153
      Location:354 → 389
      VHP; Villin headpiece domain
      pfam16182
      Location:8 → 353
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    18. NM_001322898.2 → NP_001309827.1  actin-binding LIM protein 1 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) and variant 22 both encode isoform r.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B4DQA3
      Conserved Domains (4) summary
      smart00153
      Location:345 → 380
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 343
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:144 → 242
      RIFIN; Rifin

    19. NM_001322899.2 → NP_001309828.1  actin-binding LIM protein 1 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) and variant 21 both encode isoform r.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B4DQA3
      Conserved Domains (4) summary
      smart00153
      Location:345 → 380
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33 → 343
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:144 → 242
      RIFIN; Rifin

    20. NM_001322900.2 → NP_001309829.1  actin-binding LIM protein 1 isoform t

      Status: REVIEWED

      Source sequence(s)
      AL133384
      Conserved Domains (2) summary
      smart00153
      Location:319 → 354
      VHP; Villin headpiece domain
      pfam16182
      Location:8 → 318
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    21. NM_001352440.1 → NP_001339369.1  actin-binding LIM protein 1 isoform u

      Status: REVIEWED

      Source sequence(s)
      AK297344, AL133384, AL354873, DC376979
      UniProtKB/TrEMBL
      A0A494C1G0, B7Z4H1, F8W8M4
      Related
      ENSP00000499023.2, ENST00000651023.2
      Conserved Domains (6) summary
      smart00153
      Location:620 → 655
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 618
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    22. NM_001352441.1 → NP_001339370.1  actin-binding LIM protein 1 isoform v

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL354873, DC376979
      UniProtKB/TrEMBL
      A0A9L9PY99, F8W8M4
      Related
      ENSP00000516747.1, ENST00000707119.1
      Conserved Domains (7) summary
      smart00153
      Location:585 → 620
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273 → 583
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:384 → 482
      RIFIN; Rifin

    23. NM_001352442.2 → NP_001339371.1  actin-binding LIM protein 1 isoform w

      Status: REVIEWED

      Source sequence(s)
      AK093471, AL133384, AL354873, DB039901
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (5) summary
      smart00153
      Location:556 → 591
      VHP; Villin headpiece domain
      cd09328
      Location:3 → 58
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74 → 125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133 → 188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:198 → 555
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    24. NM_001352443.2 → NP_001339372.1  actin-binding LIM protein 1 isoform x

      Status: REVIEWED

      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (3) summary
      smart00153
      Location:429 → 464
      VHP; Villin headpiece domain
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:34 → 428
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    25. NM_002313.7 → NP_002304.3  actin-binding LIM protein 1 isoform a

      See identical proteins and their annotated locations for NP_002304.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF005654, AL133384, AL354873
      Consensus CDS
      CCDS7590.1
      UniProtKB/Swiss-Prot
      A6NI16, A6NJ06, A8MXA9, B3KVH2, O14639, Q15039, Q5JVV1, Q5JVV2, Q5T6N2, Q5T6N3, Q5T6N5, Q68CQ9, Q9BUP1
      UniProtKB/TrEMBL
      A0A2Z4N5U1
      Related
      ENSP00000433629.3, ENST00000533213.7
      Conserved Domains (7) summary
      smart00153
      Location:743 → 778
      VHP; Villin headpiece domain
      cd09327
      Location:99 → 150
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:155 → 210
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:226 → 277
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:285 → 340
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:350 → 742
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:580 → 640
      Rifin_STEVOR; Rifin/stevor family

    26. NM_006720.4 → NP_006711.3  actin-binding LIM protein 1 isoform s

      See identical proteins and their annotated locations for NP_006711.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. It also uses a downstream start codon, compared to variant 1. The resulting isoform (s) is shorter, compared to isoform a.
      Source sequence(s)
      AI680726, AK058007, AK093471, AK122891, AL600892, AL710059, AW627433, BC002448, BE395092, BE672277, BG426037, BQ721521, CA450184, CB128609, CD558045, D31883
      Consensus CDS
      CCDS31289.1
      UniProtKB/TrEMBL
      B3KSG3
      Related
      ENSP00000376679.3, ENST00000392952.7
      Conserved Domains (4) summary
      smart00153
      Location:420 → 455
      VHP; Villin headpiece domain
      pfam16182
      Location:62 → 419
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:257 → 317
      Rifin_STEVOR; Rifin/stevor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      114431110..114801373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425242.1 → XP_047281198.1  actin-binding LIM protein 1 isoform X24

    2. XM_047425238.1 → XP_047281194.1  actin-binding LIM protein 1 isoform X19

    3. XM_047425237.1 → XP_047281193.1  actin-binding LIM protein 1 isoform X18

    4. XM_047425239.1 → XP_047281195.1  actin-binding LIM protein 1 isoform X20

    5. XM_047425232.1 → XP_047281188.1  actin-binding LIM protein 1 isoform X11

    6. XM_047425231.1 → XP_047281187.1  actin-binding LIM protein 1 isoform X10

    7. XM_047425240.1 → XP_047281196.1  actin-binding LIM protein 1 isoform X21

    8. XM_017016247.2 → XP_016871736.2  actin-binding LIM protein 1 isoform X14

    9. XM_047425234.1 → XP_047281190.1  actin-binding LIM protein 1 isoform X13

    10. XM_047425236.1 → XP_047281192.1  actin-binding LIM protein 1 isoform X15

    11. XM_024448011.2 → XP_024303779.2  actin-binding LIM protein 1 isoform X4

    12. XM_047425229.1 → XP_047281185.1  actin-binding LIM protein 1 isoform X3

    13. XM_024448010.2 → XP_024303778.2  actin-binding LIM protein 1 isoform X1

    14. XM_017016255.2 → XP_016871744.1  actin-binding LIM protein 1 isoform X22

      UniProtKB/TrEMBL
      F8W8M4

    15. XM_017016250.2 → XP_016871739.1  actin-binding LIM protein 1 isoform X17

      UniProtKB/TrEMBL
      F8W8M4

    16. XM_017016245.2 → XP_016871734.1  actin-binding LIM protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A3B3IS55

    17. XM_047425243.1 → XP_047281199.1  actin-binding LIM protein 1 isoform X25

    18. XM_047425233.1 → XP_047281189.1  actin-binding LIM protein 1 isoform X12

    19. XM_006717837.3 → XP_006717900.1  actin-binding LIM protein 1 isoform X5

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:753 → 788
      VHP; Villin headpiece domain
      cd09327
      Location:39 → 90
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95 → 150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166 → 217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225 → 280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:318 → 752
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    20. XM_011539802.3 → XP_011538104.2  actin-binding LIM protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS55
      Conserved Domains (6) summary
      smart00153
      Location:743 → 778
      VHP; Villin headpiece domain
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:156 → 207
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:215 → 270
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:308 → 742
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    21. XM_017016256.2 → XP_016871745.1  actin-binding LIM protein 1 isoform X26

      UniProtKB/TrEMBL
      F8W8M4

    22. XM_024448016.2 → XP_024303784.1  actin-binding LIM protein 1 isoform X16

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:709 → 744
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:274 → 708
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    23. XM_024448018.2 → XP_024303786.1  actin-binding LIM protein 1 isoform X23

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:662 → 697
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:302 → 661
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    24. XM_024448014.2 → XP_024303782.1  actin-binding LIM protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A3B3IS55
      Conserved Domains (6) summary
      smart00153
      Location:737 → 772
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150 → 201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209 → 264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:302 → 736
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    25. XM_024448013.2 → XP_024303781.1  actin-binding LIM protein 1 isoform X7

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (5) summary
      smart00153
      Location:633 → 668
      VHP; Villin headpiece domain
      cd09328
      Location:3 → 58
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74 → 125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133 → 188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:198 → 632
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    26. XM_011539801.3 → XP_011538103.2  actin-binding LIM protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IS55
      Conserved Domains (5) summary
      smart00153
      Location:661 → 696
      VHP; Villin headpiece domain
      cd09328
      Location:3 → 58
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74 → 125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133 → 188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:226 → 660
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    27. XM_006717846.4 → XP_006717909.1  actin-binding LIM protein 1 isoform X27

      See identical proteins and their annotated locations for XP_006717909.1

      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:497 → 532
      VHP; Villin headpiece domain
      pfam16182
      Location:62 → 496
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:334 → 394
      Rifin_STEVOR; Rifin/stevor family

    28. XM_047425245.1 → XP_047281201.1  actin-binding LIM protein 1 isoform X29

    29. XM_047425244.1 → XP_047281200.1  actin-binding LIM protein 1 isoform X28

    30. XM_047425246.1 → XP_047281202.1  actin-binding LIM protein 1 isoform X30

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      115325183..115686686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365923.1 → XP_054221898.1  actin-binding LIM protein 1 isoform X39

    2. XM_054365924.1 → XP_054221899.1  actin-binding LIM protein 1 isoform X40

    3. XM_054365913.1 → XP_054221888.1  actin-binding LIM protein 1 isoform X34

    4. XM_054365907.1 → XP_054221882.1  actin-binding LIM protein 1 isoform X31

    5. XM_054365933.1 → XP_054221908.1  actin-binding LIM protein 1 isoform X45

    6. XM_054365928.1 → XP_054221903.1  actin-binding LIM protein 1 isoform X42

    7. XM_054365927.1 → XP_054221902.1  actin-binding LIM protein 1 isoform X41

    8. XM_054365929.1 → XP_054221904.1  actin-binding LIM protein 1 isoform X43

    9. XM_054365919.1 → XP_054221894.1  actin-binding LIM protein 1 isoform X36

    10. XM_054365918.1 → XP_054221893.1  actin-binding LIM protein 1 isoform X35

    11. XM_054365908.1 → XP_054221883.1  actin-binding LIM protein 1 isoform X7

    12. XM_054365930.1 → XP_054221905.1  actin-binding LIM protein 1 isoform X44

    13. XM_054365922.1 → XP_054221897.1  actin-binding LIM protein 1 isoform X38

    14. XM_054365921.1 → XP_054221896.1  actin-binding LIM protein 1 isoform X37

    15. XM_054365911.1 → XP_054221886.1  actin-binding LIM protein 1 isoform X33

    16. XM_054365910.1 → XP_054221885.1  actin-binding LIM protein 1 isoform X32

    17. XM_054365931.1 → XP_054221906.1  actin-binding LIM protein 1 isoform X22

    18. XM_054365926.1 → XP_054221901.1  actin-binding LIM protein 1 isoform X17

    19. XM_054365917.1 → XP_054221892.1  actin-binding LIM protein 1 isoform X9

    20. XM_054365934.1 → XP_054221909.1  actin-binding LIM protein 1 isoform X25

    21. XM_054365920.1 → XP_054221895.1  actin-binding LIM protein 1 isoform X12

    22. XM_054365912.1 → XP_054221887.1  actin-binding LIM protein 1 isoform X5

    23. XM_054365914.1 → XP_054221889.1  actin-binding LIM protein 1 isoform X6

    24. XM_054365935.1 → XP_054221910.1  actin-binding LIM protein 1 isoform X26

    25. XM_054365925.1 → XP_054221900.1  actin-binding LIM protein 1 isoform X16

    26. XM_054365932.1 → XP_054221907.1  actin-binding LIM protein 1 isoform X23

    27. XM_054365916.1 → XP_054221891.1  actin-binding LIM protein 1 isoform X8

    28. XM_054365936.1 → XP_054221911.1  actin-binding LIM protein 1 isoform X2

    29. XM_054365915.1 → XP_054221890.1  actin-binding LIM protein 1 isoform X7

    30. XM_054365909.1 → XP_054221884.1  actin-binding LIM protein 1 isoform X2

    31. XM_054365937.1 → XP_054221912.1  actin-binding LIM protein 1 isoform X27

    32. XM_054365939.1 → XP_054221914.1  actin-binding LIM protein 1 isoform X47

    33. XM_054365938.1 → XP_054221913.1  actin-binding LIM protein 1 isoform X46

    34. XM_054365940.1 → XP_054221915.1  actin-binding LIM protein 1 isoform X30

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003408.1: Suppressed sequence

      Description
      NM_001003408.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14639.3 GenPept UniProtKB/Swiss-Prot:O14639

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