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    Gcdh glutaryl-CoA dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364975, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gcdhprovided by RGD
    Official Full Name
    glutaryl-CoA dehydrogenaseprovided by RGD
    Primary source
    RGD:1308829
    See related
    EnsemblRapid:ENSRNOG00000003307 AllianceGenome:RGD:1308829
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Involved in fatty acid oxidation and fatty-acyl-CoA biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 1777.2), Liver (RPKM 1242.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gcdh in Genome Data Viewer
    Location:
    19q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40168038..40174536)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23263215..23269689)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26000497..26006970, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 2, lysosomal Neighboring gene KLF transcription factor 1 Neighboring gene synaptonemal complex central element protein 2 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene calreticulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunolocalization of glutaryl-CoA dehydrogenase (GCDH) in adult and embryonic rat brain and peripheral tissues. Braissant O, et al. Neuroscience, 2017 Feb 20. PMID 27984186
    2. Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons. Gao J, et al. PLoS One, 2013. PMID 23658800, Free PMC Article
    3. Organic aciduria in the riboflavin-deficient rat. Goodman SI. Am J Clin Nutr, 1981 Nov. PMID 6895440
    4. Enzymes of fatty acid beta-oxidation in developing brain. Reichmann H, et al. J Neurochem, 1988 Aug. PMID 2899130
    5. The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery. Gonzalez Melo M, et al. Mol Genet Metab, 2021 Jun. PMID 33965309

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery.
      Title: The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery.
    2. GCDH was found widely expressed in embryonic and adult rat tissues. In rat embryos GCDH is predominantly expressed in brain implying an important role for brain development. Interestingly, GCDH was found to be significantly expressed in different other organs (e.g. kidney, gut) in adult rats probably explaining the evolving phenotype in GA-I patients.
      Title: Immunolocalization of glutaryl-CoA dehydrogenase (GCDH) in adult and embryonic rat brain and peripheral tissues.
    3. GA1-induced striatal degeneration is partially caspase-dependent
      Title: Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaryl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaryl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaryl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty-acyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutaryl-CoA dehydrogenase, mitochondrial
    Names
    glutaryl-Coenzyme A dehydrogenase
    NP_001102366.1
    XP_063134240.1
    XP_063134241.1
    XP_063134242.1
    XP_063134243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108896.1 → NP_001102366.1  glutaryl-CoA dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_001102366.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A0A8I5ZN89, A6IY64
      Related
      ENSRNOP00000079491.2, ENSRNOT00000103013.2
      Conserved Domains (2) summary
      cd01151
      Location:57 → 443
      GCD; Glutaryl-CoA dehydrogenase
      COG1960
      Location:69 → 443
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40168038..40174536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278170.1 → XP_063134240.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X1

    2. XM_063278171.1 → XP_063134241.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X2

    3. XM_063278172.1 → XP_063134242.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X3

    4. XM_063278173.1 → XP_063134243.1  glutaryl-CoA dehydrogenase, mitochondrial isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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