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    Cbfb core-binding factor subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361391, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cbfbprovided by RGD
    Official Full Name
    core-binding factor subunit betaprovided by RGD
    Primary source
    RGD:620493
    See related
    Ensembl:ENSRNOG00000014647 AllianceGenome:RGD:620493
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pebp2
    Summary
    Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; protein polyubiquitination; and regulation of alpha-beta T cell differentiation. Predicted to act upstream of or within several processes, including hemopoiesis; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core-binding activity factor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 458.7), Spleen (RPKM 284.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cbfb in Genome Data Viewer
    Location:
    19q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (49955133..50002661)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33049162..33092752)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37127508..37171075)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L27, pseudogene 10 Neighboring gene phagosome assembly factor 1 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene TNFRSF1A-associated via death domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. Chen G, et al. J Neurochem, 1999 Feb. PMID 9930766
    2. RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries. Park ES, et al. Mol Endocrinol, 2010 Apr. PMID 20197312, Free PMC Article
    3. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. Yamamoto CM, et al. J Leukoc Biol, 2004 Feb. PMID 14634060
    4. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Liu P, et al. Science, 1993 Aug 20. PMID 8351518
    5. Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis. Miyagawa K, et al. Anticancer Res, 2006 Sep-Oct. PMID 17094378

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrated that proximity of the CAAT box and a putative polyoma enhancer-binding protein 2/core-binding factor PEBP2/CBF site was important for defensin NP-3 promoter activity.
      Title: Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of CD4-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of core-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    core-binding factor subunit beta
    Names
    core binding factor beta
    core-binding factor, beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013191.1 → NP_001013209.1  core-binding factor subunit beta

      See identical proteins and their annotated locations for NP_001013209.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081946
      UniProtKB/TrEMBL
      Q66HA7
      Related
      ENSRNOP00000019656.4, ENSRNOT00000019656.5
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 167
      CBF_beta; Core binding factor beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      49955133..50002661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255502.5 → XP_006255564.1  core-binding factor subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006255564.1

      UniProtKB/TrEMBL
      A0A8I5ZT73, A0A8I6GMB2, A6IYM1
      Related
      ENSRNOP00000097999.1
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 167
      CBF_beta; Core binding factor beta subunit

    2. XM_039097826.2 → XP_038953754.1  core-binding factor subunit beta isoform X2

      Conserved Domains (1) summary
      pfam02312
      Location:2 → 113
      CBF_beta; Core binding factor beta subunit

    3. XM_039097827.2 → XP_038953755.1  core-binding factor subunit beta isoform X3

      Conserved Domains (1) summary
      pfam02312
      Location:2 → 113
      CBF_beta; Core binding factor beta subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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