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    Luc7l2 LUC7-like 2 pre-mRNA splicing factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312251, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Luc7l2provided by RGD
    Official Full Name
    LUC7-like 2 pre-mRNA splicing factorprovided by RGD
    Primary source
    RGD:1308651
    See related
    Ensembl:ENSRNOG00000006001 AllianceGenome:RGD:1308651
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity and mRNA binding activity. Predicted to be involved in mRNA splice site selection. Predicted to be located in nuclear speck. Predicted to be part of U1 snRNP and U2-type prespliceosome. Orthologous to human LUC7L2 (LUC7 like 2, pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 214.6), Adrenal (RPKM 188.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Luc7l2 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (68251435..68314861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (67287593..67347986)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (66290319..66357970)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon CCU) 2 Neighboring gene formation of mitochondrial complex V assembly factor 1 Neighboring gene small nuclear ribonucleoprotein E-like Neighboring gene insulin-induced gene 1 protein-like Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene killer cell lectin like receptor G2 Neighboring gene C-type lectin domain family 2, member L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Webby CJ, et al. Science, 2009 Jul 3. PMID 19574390
    2. Evidence for a direct role of the disease modifier SCNM1 in splicing. Howell VM, et al. Hum Mol Genet, 2007 Oct 15. PMID 17656373
    3. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative RNA-binding protein Luc7-like 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107853.1 → NP_001101323.1  putative RNA-binding protein Luc7-like 2

      See identical proteins and their annotated locations for NP_001101323.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      B2RYP6, F1LP75
      Conserved Domains (1) summary
      pfam03194
      Location:5 → 241
      LUC7; LUC7 N_terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      68251435..68314861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286004.1 → XP_063142074.1  putative RNA-binding protein Luc7-like 2 isoform X6

    2. XM_006236316.5 → XP_006236378.1  putative RNA-binding protein Luc7-like 2 isoform X2

      See identical proteins and their annotated locations for XP_006236378.1

      UniProtKB/TrEMBL
      A0A8J8XLZ3
      Conserved Domains (1) summary
      pfam03194
      Location:26 → 240
      LUC7; LUC7 N_terminus

    3. XM_063286003.1 → XP_063142073.1  putative RNA-binding protein Luc7-like 2 isoform X5

    4. XM_006236321.4 → XP_006236383.1  putative RNA-binding protein Luc7-like 2 isoform X4

      See identical proteins and their annotated locations for XP_006236383.1

      Related
      ENSRNOP00000086709.1
      Conserved Domains (1) summary
      pfam03194
      Location:5 → 241
      LUC7; LUC7 N_terminus

    5. XM_006236323.4 → XP_006236385.1  putative RNA-binding protein Luc7-like 2 isoform X7

      See identical proteins and their annotated locations for XP_006236385.1

      UniProtKB/TrEMBL
      A0A8I5Y5L3
      Conserved Domains (1) summary
      pfam03194
      Location:1 → 188
      LUC7; LUC7 N_terminus

    6. XM_006236322.5 → XP_006236384.1  putative RNA-binding protein Luc7-like 2 isoform X7

      See identical proteins and their annotated locations for XP_006236384.1

      UniProtKB/TrEMBL
      A0A8I5Y5L3
      Related
      ENSRNOP00000077278.1
      Conserved Domains (1) summary
      pfam03194
      Location:1 → 188
      LUC7; LUC7 N_terminus

    7. XM_063286000.1 → XP_063142070.1  putative RNA-binding protein Luc7-like 2 isoform X1

    8. XM_063286001.1 → XP_063142071.1  putative RNA-binding protein Luc7-like 2 isoform X2

      UniProtKB/TrEMBL
      A0A8J8XLZ3

    9. XM_006236315.5 → XP_006236377.1  putative RNA-binding protein Luc7-like 2 isoform X2

      See identical proteins and their annotated locations for XP_006236377.1

      UniProtKB/TrEMBL
      A0A8J8XLZ3
      Related
      ENSRNOP00000008557.6
      Conserved Domains (1) summary
      pfam03194
      Location:26 → 240
      LUC7; LUC7 N_terminus

    10. XM_063286002.1 → XP_063142072.1  putative RNA-binding protein Luc7-like 2 isoform X3

    11. XM_039107522.2 → XP_038963450.1  putative RNA-binding protein Luc7-like 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y5L3
      Conserved Domains (1) summary
      pfam03194
      Location:1 → 188
      LUC7; LUC7 N_terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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