ANP32CP acidic nuclear phosphoprotein 32 family member C, pseudogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANP32CPprovided by HGNC
Official Full Name: acidic nuclear phosphoprotein 32 family member C, pseudogeneprovided by HGNC
Primary source: HGNC:HGNC:16675
See related: MIM:606877; AllianceGenome:HGNC:16675
Gene type: pseudo
RefSeq status: INFERRED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANP32C; PP32R1
Summary: Predicted to enable histone binding activity. Predicted to be involved in nucleocytoplasmic transport and regulation of apoptotic process. Predicted to be active in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 4q32.3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (164196840..164197821, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (167544545..167545526, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (165117992..165118973, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results highlight that certain malignancies with ANP32C/D overexpression or mutation might be specifically targeted using Hsp90 inhibitors.
Title: Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90.
These findings highlight that certain cancers overexpressing pp32r1 or pp32r1 mutants are likely to demonstrate enhanced resistance to FTY720 treatment.
Title: Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod).
pp32r1 binds to HuR to avoid the caspase-mediated decay of HuR in the cytoplasm of cells.
Title: pp32r1 controls the decay of the RNA-binding protein HuR.
CHD4 were significantly upregulated by pp32r1 and pp32r1Y140H overexpression which influence a number of cell cycle regulator genes including p53, p21 and cyclinD1
Title: Dysregulation of cell cycle control caused by overexpression of the oncogene pp32r1 (ANP32C) and the Tyr>His mutant pp32r1Y140H.
expression levels vary among human tumor cell lines, with the highest levels found in prostatic adenocarcinoma cell lines
Title: Identification of a functional mutation in pp32r1 (ANP32C).

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
acidic nuclear phosphoprotein 32 family member C
phosphoprotein 32-related protein 1
pp32 related 1
tumorigenic protein pp32r1

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nucleocytoplasmic transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_074974.1

Range

101..1082

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GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

164196840..164197821 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

167544545..167545526 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001388483.1: Suppressed sequence

Description

NM_001388483.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
NM_012403.1: Suppressed sequence

Description

NM_012403.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.