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    DUSP14 dual specificity phosphatase 14 [ Homo sapiens (human) ]

    Gene ID: 11072, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DUSP14provided by HGNC
    Official Full Name
    dual specificity phosphatase 14provided by HGNC
    Primary source
    HGNC:HGNC:17007
    See related
    Ensembl:ENSG00000276023 MIM:606618; AllianceGenome:HGNC:17007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKP6; MKP-L
    Summary
    Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
    Expression
    Broad expression in thyroid (RPKM 9.3), skin (RPKM 8.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DUSP14 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37488566..37513498)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38472550..38500180)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35849997..35873600)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene chromosome 17 open reading frame 78 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35768105-35768789 Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene synergin gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210 Neighboring gene microRNA 378j Neighboring gene DExD-box helicase 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. Lountos GT, et al. Acta Crystallogr D Biol Crystallogr, 2009 Oct. PMID 19770498, Free PMC Article
    2. Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Barreiro LB, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22233810, Free PMC Article
    3. Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis. Hijikata M, et al. Genes Immun, 2016 Jun. PMID 26938665
    4. Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages. Elass E, et al. FEBS Lett, 2008 Feb 6. PMID 18201568
    5. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Yang CY, et al. Cell Signal, 2016 Jan. PMID 26521044

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bioinformatic studies showed that these two miRNAs target PTEN and DUSP14 tumor suppressor genes. Quantitative Real-time PCR confirmed the overexpression of the miRNAs and downregulation of their targets. Luciferase assay confirmed that the miRNAs target PTEN and DUSP14.
      Title: Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells.
    2. Hepatocyte DUSP14 is required for maintaining hepatic metabolic homeostasis and for suppressing inflammation, a novel function that relies on constraining TAK1 hyperactivation
      Title: Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver.
    3. The AA genotype was associated with protection against active TB. Among disease-free individuals, T-helper type-1 related genes, IFNGR2 and STAT1 mRNA levels significantly increased as the number of A alleles of rs1051838 increased.
      Title: Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis.
    4. levels significantly decreased in failing hearts
      Title: Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.
    5. these findings reveal a novel mechanism by which TRAF2 mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14 activation in T cells
      Title: TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity.
    6. findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187
      Title: The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-κB activation by dephosphorylating the protein kinase TAK1.
    7. DUSP14 may be a susceptibility gene for pulmonary tuberculosis.
      Title: Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
    8. The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported.
      Title: Overproduction, purification and structure determination of human dual-specificity phosphatase 14.
    9. The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation.
      Title: Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.
    10. Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1.
      Title: Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
    EBI GWAS Catalog
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 14
    Names
    MAP kinase phosphatase 6
    MKP-1-like protein tyrosine phosphatase
    MKP-6
    mitogen-activated protein kinase phosphatase 6
    NP_008957.1
    XP_005257034.1
    XP_011522536.1
    XP_047291173.1
    XP_054170826.1
    XP_054170827.1
    XP_054170828.1
    XP_054170829.1
    XP_054185204.1
    XP_054185205.1
    XP_054185206.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007026.4 → NP_008957.1  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_008957.1

      Status: VALIDATED

      Source sequence(s)
      AC243585, AC243654
      Consensus CDS
      CCDS11320.1
      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
      Related
      ENSP00000478595.1, ENST00000617516.5
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      37488566..37513498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524234.2 → XP_011522536.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_011522536.1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    2. XM_047435217.1 → XP_047291173.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    3. XM_005256977.4 → XP_005257034.1  dual specificity protein phosphatase 14 isoform X1

      See identical proteins and their annotated locations for XP_005257034.1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
      Related
      ENSP00000484091.1, ENST00000613659.1
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1725025..1752665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329231.1 → XP_054185206.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    2. XM_054329230.1 → XP_054185205.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    3. XM_054329229.1 → XP_054185204.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      38472550..38500180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314854.1 → XP_054170829.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    2. XM_054314853.1 → XP_054170828.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    3. XM_054314851.1 → XP_054170826.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36

    4. XM_054314852.1 → XP_054170827.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      O95147
      UniProtKB/TrEMBL
      Q6FI36
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95147.1 GenPept UniProtKB/Swiss-Prot:O95147

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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