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    FER1L4 fer-1 like family member 4 (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 80307, updated on 17-Jun-2024

    Summary

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    Official Symbol
    FER1L4provided by HGNC
    Official Full Name
    fer-1 like family member 4 (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:15801
    See related
    Ensembl:ENSG00000088340 AllianceGenome:HGNC:15801
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf124
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in plasma membrane organization. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach (RPKM 27.2), urinary bladder (RPKM 7.3) and 4 other tissues See more
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    Genomic context

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    See FER1L4 in Genome Data Viewer
    Location:
    20q11.22
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (35558737..35607562, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37279572..37328533, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34146507..34195484, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17786 Neighboring gene ERGIC and golgi 3 Neighboring gene ribosomal protein L36 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:34145795-34145976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34146815-34147316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34147317-34147816 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:34164928-34165090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:34176389-34176889 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:34177977-34178478 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:34178479-34178978 Neighboring gene ribosomal protein L37 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34187074-34187574 Neighboring gene uncharacterized LOC124904891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34205257-34206207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34206208-34207157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17789 Neighboring gene sperm associated antigen 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:34223677-34224176 Neighboring gene copine 1 Neighboring gene RN7SK pseudogene 271

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors. Mou J, et al. Curr Pharm Des, 2022. PMID 35331091
    2. Long non‑coding RNA fer‑1‑like family member 4 serves as a tumor suppressor in laryngeal squamous cell carcinoma cells via regulating the AKT/ERK signaling pathway. Jiao L, et al. Mol Med Rep, 2020 Dec. PMID 33174027, Free PMC Article
    3. The lncRNA Fer1L4 is an adverse prognostic parameter in clear-cell renal-cell carcinoma. Cox A, et al. Clin Transl Oncol, 2020 Sep. PMID 31965534, Free PMC Article
    4. Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan-cancer. You Z, et al. J Cell Physiol, 2020 Feb. PMID 31332783
    5. Long non‑coding RNA FER1L4 inhibits cell proliferation and metastasis through regulation of the PI3K/AKT signaling pathway in lung cancer cells. Gao X, et al. Mol Med Rep, 2019 Jul. PMID 31115514, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and Alteration Value of Long Noncoding RNA AB073614 and FER1L4 in Patients with Acute Myeloid Leukemia (AML).
      Title: Expression and Alteration Value of Long Noncoding RNA AB073614 and FER1L4 in Patients with Acute Myeloid Leukemia (AML).
    2. FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors.
      Title: FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors.
    3. Correlation between expression levels of lncRNA FER1L4 and RB1 in patients with colorectal cancer.
      Title: Correlation between expression levels of lncRNA FER1L4 and RB1 in patients with colorectal cancer.
    4. lncRNA FER1L4 is dysregulated in osteoarthritis and regulates IL-6 expression in human chondrocyte cells.
      Title: lncRNA FER1L4 is dysregulated in osteoarthritis and regulates IL-6 expression in human chondrocyte cells.
    5. Long noncoding RNA FER1L4 inhibits cell proliferation and promotes cell apoptosis via the PTEN/AKT/p53 signaling pathway in lung cancer.
      Title: Long non‑coding RNA FER1L4 inhibits cell proliferation and promotes cell apoptosis via the PTEN/AKT/p53 signaling pathway in lung cancer.
    6. The lncRNA Fer1L4 is an adverse prognostic parameter in clear-cell renal-cell carcinoma.
      Title: The lncRNA Fer1L4 is an adverse prognostic parameter in clear-cell renal-cell carcinoma.
    7. Long noncoding RNA fer1like family member 4 serves as a tumor suppressor in laryngeal squamous cell carcinoma cells via regulating the AKT/ERK signaling pathway.
      Title: Long non‑coding RNA fer‑1‑like family member 4 serves as a tumor suppressor in laryngeal squamous cell carcinoma cells via regulating the AKT/ERK signaling pathway.
    8. Dysregulation of Transcription Factor Activity During Formation of Cancer-Associated Fibroblasts.
      Title: Dysregulation of Transcription Factor Activity During Formation of Cancer-Associated Fibroblasts.
    9. Long non-coding RNA FER1L4 promotes osteogenic differentiation of human periodontal ligament stromal cells via miR-874-3p and vascular endothelial growth factor A.
      Title: Long non-coding RNA FER1L4 promotes osteogenic differentiation of human periodontal ligament stromal cells via miR-874-3p and vascular endothelial growth factor A.
    10. Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan-cancer.
      Title: Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan-cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • fer-1 like family member 4, pseudogene (functional)
    • fer-1-like 4, pseudogene (functional)

    Clone Names

    • FLJ13459, FLJ22613, DKFZp686F01207

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_119376.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI440245, AY461812, BC029951, BX648024, DA854396, FO393401
      Related
      ENST00000615531.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      35558737..35607562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      37279572..37328533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025206.1: Suppressed sequence

      Description
      NM_025206.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NR_001442.2: Suppressed sequence

      Description
      NR_001442.2: This RefSeq was suppressed permanently based on the re-evaluation of this gene as protein-coding.

    3. NR_024377.1: Suppressed sequence

      Description
      NR_024377.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version

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