Zbtb33 zinc finger and BTB domain containing 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb33provided by MGI
Official Full Name: zinc finger and BTB domain containing 33provided by MGI
Primary source: MGI:MGI:1927290
See related: Ensembl:ENSMUSG00000048047 AllianceGenome:MGI:1927290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kaiso; Znf-kaiso; E130014G12Rik
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to act upstream of or within DNA-templated transcription. Located in nucleus. Is expressed in several structures, including bladder; central nervous system; early conceptus; eye; and gonad. Orthologous to human ZBTB33 (zinc finger and BTB domain containing 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.7), CNS E18 (RPKM 8.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A3.3; X 22.45 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (37278670..37285923)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (38189793..38197046)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
Title: Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
[Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3, small es, Cyrillic-capital EM, Cyrillicsmall u, Cyrillicsmall es, Cyrillic and FoxG1 Genes in the Developing Mouse Brain].
Title: [Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3, с-Мус and FoxG1 Genes in the Developing Mouse Brain].
Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells.
Title: Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells.
Authors used Kaiso-deficient mice to conditionally delete Apc within the intestinal epithelia and demonstrated upregulation of the spindle polarity genes Dlg1 and Dlgap1.
Title: Epigenetic Regulation of Dlg1, via Kaiso, Alters Mitotic Spindle Polarity and Promotes Intestinal Tumorigenesis.
The proposed mechanisms for the increase in the efficiency of somatic reprogramming associated with the Kaiso gene knockout is a decrease in the methylation level of the Oct4 promoter region in mouse embryonic fibroblasts before reprogramming.
Title: Kaiso Gene Knockout Promotes Somatic Cell Reprogramming.
We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes.
Title: The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes.
Kaiso and Sox10 sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.
Title: Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.
Study revealed the involvement of the Zbtb33 gene and, probably, the Kaiso protein in the regulation of locomotion and brain morphology in mice
Title: Knockout Zbtb33 gene results in an increased locomotion, exploration and pre-pulse inhibition in mice.
a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported.
Title: Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression.
S100A3 is a new target gene of Kaiso in mouse skin
Title: [S100A3 is a new target gene of Kaiso in mouse skin].

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW260253 (e-PCR)
- UniSTS:181283

Zbtb33 (e-PCR), detects polymorphism
- UniSTS:532290

UniSTS:238015 (e-PCR)
- UniSTS:238015

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyl-CpG binding	IEA Inferred from Electronic Annotation more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	ISA Inferred from Sequence Alignment more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional regulator Kaiso

Names: zinc finger and BTB domain-containing protein 33; zinc finger transcription factor Kaiso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079513.1 → NP_001072981.1 transcriptional regulator Kaiso

See identical proteins and their annotated locations for NP_001072981.1

Status: VALIDATED

Source sequence(s)

AK087417, AL512346, BY200826

Consensus CDS

CCDS30088.1

UniProtKB/Swiss-Prot

Q8BN78, Q8C226, Q9WTZ7

UniProtKB/TrEMBL

A2A3Z2, A2A3Z3

Related

ENSMUSP00000110795.3, ENSMUST00000115142.3

Conserved Domains (4) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:494 → 514

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain

pfam13465
Location:506 → 529

zf-H2C2_2; Zinc-finger double domain
NM_020256.2 → NP_064652.2 transcriptional regulator Kaiso

See identical proteins and their annotated locations for NP_064652.2

Status: VALIDATED

Source sequence(s)

AK087417, AK089423, AL512346, BY200826

Consensus CDS

CCDS30088.1

UniProtKB/Swiss-Prot

Q8BN78, Q8C226, Q9WTZ7

UniProtKB/TrEMBL

A2A3Z2, A2A3Z3

Related

ENSMUSP00000049983.3, ENSMUST00000049740.3

Conserved Domains (4) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:494 → 514

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain

pfam13465
Location:506 → 529

zf-H2C2_2; Zinc-finger double domain