H1f4 H1.4 linker histone, cluster member [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H1f4provided by RGD
Official Full Name: H1.4 linker histone, cluster memberprovided by RGD
Primary source: RGD:2776
See related: AllianceGenome:RGD:2776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H14; H1d; H1-4; Hist1h1c; Hist1h1d; Hist1h1e
Summary: Enables calcium ion binding activity; double-stranded DNA binding activity; and purine nucleotide binding activity. Predicted to be involved in chromosome condensation. Predicted to act upstream of or within histone lysine methylation; negative regulation of transcription by RNA polymerase II; and nucleosome positioning. Part of nucleosome. Orthologous to human H1-4 (H1.4 linker histone, cluster member). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41914425..41915206)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41486574..41487355)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43734461..43735120)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data presented herein regarding chromatin remodeling indirectly support the hypothesis that LOX binds to histone H1 in vivo.
Title: Chromatin supraorganization, mitotic abnormalities and proliferation in cells with increased or down-regulated lox expression: Indirect evidence of a LOX-histone H1 interaction in vivo.
Prediction of an HMG-box fold in the C-terminal domain of histone H1d: insights into its role in DNA condensation
Title: Prediction of an HMG-box fold in the C-terminal domain of histone H1: insights into its role in DNA condensation.
A 34 amino acid stretch (residues 184-218) in the C-terminus of histone H1d has been identified as the DNA-condensing domain; when entirely deleted, there is nearly a 90% decrease in DNA condensation.
Title: Identification of a 34 amino acid stretch within the C-terminus of histone H1 as the DNA-condensing domain by site-directed mutagenesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables AMP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	EXP Inferred from Experiment more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables dATP binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of chromatin	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromosome condensation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	TAS Traceable Author Statement more info	PubMed
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H1.4

Names: H1 histone family, member 4; Histone 1d; histone H1.2; histone cluster 1 H1 family member e; histone cluster 1, H1d; histone cluster 1, H1e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133285.2 → NP_579819.1 histone H1.4

See identical proteins and their annotated locations for NP_579819.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P15865

UniProtKB/TrEMBL

A6KLN4

Conserved Domains (1) summary

pfam00538
Location:38 → 108

Linker_histone; linker histone H1 and H5 family