Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gucy1b1provided by RGD
Official Full Name: guanylate cyclase 1 soluble subunit beta 1provided by RGD
Primary source: RGD:2769
See related: EnsemblRapid:ENSRNOG00000012060 AllianceGenome:RGD:2769
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SGC; Gucy1b3
Summary: Enables Hsp90 protein binding activity; heme binding activity; and ion binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; cellular response to nitric oxide; and nitric oxide-cGMP-mediated signaling pathway. Located in presynaptic active zone. Part of guanylate cyclase complex, soluble. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Orthologous to human GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 385.0), Lung (RPKM 276.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (169646897..169697060, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (167348824..167398983, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (180976939..181026001, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FoxO4 controls sGCbeta transcription in vascular smooth muscle.
Title: FoxO4 controls sGCβ transcription in vascular smooth muscle.
GUCY1B3 was upregulated in neonatal rat ventricular myocytes in response to ischemia and reperfusion (IR) injury, and restored IR-induced cell death and apoptosis. Other results suggest that GUCY1B3 has an antiapoptotic effect and this effect is mediated by the activation of PKCepsilon and Akt.
Title: The β subunit of soluble guanylyl cyclase GUCY1B3 exerts cardioprotective effects against ischemic injury via the PKCε/Akt pathway.
The effect of glucagon-like peptide-2 on the expression of the alpha1, alpha2, and beta1 subunits of soluble guanylyl cyclase, was studied.
Title: Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes.
soluble GCbeta1 plays an important role in the restructuring of the adherens junction in the testis [sGCbeta1]
Title: Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions.
Identify hydrogen peroxide as an endogenous mediator contributing to the regulation of vascular tone and point to a key role of HuR in sGCbeta1 mRNA stabilization.
Title: H2O2 regulation of vascular function through sGC mRNA stabilization by HuR.
Soluble guanylate cyclase is activated by binding of carbon monoxide and YC-1.
Title: Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.
soluble guanylate cyclase beta 1 expression in the vasculature of rat skeletal muscle
Title: The expression of soluble guanylate cyclase in the vasculature of rat skeletal muscle.
Soluble guanylyl cyclase activity is an important element not only in neurite outgrowth but also in synapse formation and maturation in cerebellar granule cells.
Title: Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
Report distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
Title: Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
beta1 is a multifunctional protein that regulates chromatin condensation and cell cycle progression, in addition to being an obligate monomer in functional nitric oxide-sensitive guanylyl cyclase heterodimers.
Title: NO-sensitive guanylyl cyclase beta1 subunit is peripherally associated to chromosomes during mitosis. Novel role in chromatin condensation and cell cycle progression.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

RH140703 (e-PCR)
- UniSTS:222770

D2Mgh17 (e-PCR)
- UniSTS:239673

RH133401 (e-PCR)
- UniSTS:216684

RH142298 (e-PCR)
- UniSTS:231545

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cytidylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables guanylate cyclase activity	TAS Traceable Author Statement more info	PubMed
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric oxide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitric oxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide-cGMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxygen levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in trans-synaptic signaling by nitric oxide, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of guanylate cyclase complex, soluble	IBA Inferred from Biological aspect of Ancestor more info
part_of guanylate cyclase complex, soluble	IDA Inferred from Direct Assay more info	PubMed
part_of guanylate cyclase complex, soluble	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylate cyclase soluble subunit beta-1

Names: GCS-beta-1; GCS-beta-3; guanylate cyclase 1 soluble subunit beta 3; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; soluble guanylate cyclase small subunit; soluble guanylyl cyclase beta 1 subunit

NP_036901.2

EC 4.6.1.2

XP_038957692.1

EC 4.6.1.2

XP_038957693.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012769.2 → NP_036901.2 guanylate cyclase soluble subunit beta-1

See identical proteins and their annotated locations for NP_036901.2

Status: PROVISIONAL

Source sequence(s)

BC081840

UniProtKB/Swiss-Prot

P20595, Q8CH88

UniProtKB/TrEMBL

A6J5T8, Q80WY4, Q80WY5, Q8CH85

Related

ENSRNOP00000062785.1, ENSRNOT00000064930.4

Conserved Domains (4) summary

smart00044
Location:385 → 584

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:412 → 605

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:2 → 166

HNOB; Haem-NO-binding

pfam07701
Location:207 → 406

HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

169646897..169697060 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101764.2 → XP_038957692.1 guanylate cyclase soluble subunit beta-1 isoform X1

UniProtKB/TrEMBL

Q80WY5

Conserved Domains (3) summary

pfam00211
Location:344 → 537

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07700
Location:1 → 98

HNOB; Haem-NO-binding

pfam07701
Location:139 → 338

HNOBA; Heme NO binding associated
XM_039101765.2 → XP_038957693.1 guanylate cyclase soluble subunit beta-1 isoform X2

Conserved Domains (2) summary

pfam07700
Location:2 → 166

HNOB; Haem-NO-binding

pfam07701
Location:207 → 327

HNOBA; Heme NO binding associated