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    CNTN4 contactin 4 [ Homo sapiens (human) ]

    Gene ID: 152330, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CNTN4provided by HGNC
    Official Full Name
    contactin 4provided by HGNC
    Primary source
    HGNC:HGNC:2174
    See related
    Ensembl:ENSG00000144619 MIM:607280; AllianceGenome:HGNC:2174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AXCAM; BIG-2
    Summary
    This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
    Expression
    Broad expression in endometrium (RPKM 2.7), thyroid (RPKM 2.4) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CNTN4 in Genome Data Viewer
    Location:
    3p26.3-p26.2
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (2098866..3057959)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (2092772..3052283)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (2140550..3099643)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr3:2136506-2137113 Neighboring gene uncharacterized LOC124909338 Neighboring gene RN7SK pseudogene 144 Neighboring gene CNTN4 antisense RNA 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68491 Neighboring gene meiotic recombination hotspot T Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68954 Neighboring gene histidine triad nucleotide binding protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19336 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:2806697-2807249 Neighboring gene NANOG hESC enhancer GRCh37_chr3:2812162-2812685 Neighboring gene uncharacterized LOC105376926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19340 Neighboring gene MPRA-validated peak4526 silencer Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_69430 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:3079797-3080996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19342 Neighboring gene CNTN4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19343 Neighboring gene uncharacterized LOC124909339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14009 Neighboring gene interleukin 5 receptor subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The contactin 4 gene locus at 3p26 is a candidate gene of SCA16. Miura S, et al. Neurology, 2006 Oct 10. PMID 17030759
    2. CpG island hypermethylation in human astrocytomas. Wu X, et al. Cancer Res, 2010 Apr 1. PMID 20233874, Free PMC Article
    3. A novel splice variant of the cell adhesion molecule contactin 4 ( CNTN4) is mainly expressed in human brain. Zeng L, et al. J Hum Genet, 2002. PMID 12202991
    4. Contactin 4 as an autism susceptibility locus. Cottrell CE, et al. Autism Res, 2011 Jun. PMID 21308999, Free PMC Article
    5. Nanomechanics of Ig-like domains of human contactin (BIG-2). Mikulska K, et al. J Mol Model, 2011 Sep. PMID 21445711, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNTN4 modulates neural elongation through interplay with APP.
      Title: CNTN4 modulates neural elongation through interplay with APP.
    2. PPARGC1B and CNTN4 genotypes are associated with elevated thromboxane A2 formation and with an excess of cardiovascular events. Aspirin appears to blunt these associations.
      Title: Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A(2) formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
    3. High CNTN4 expression is associated with Pheochromocytomas and Paragangliomas.
      Title: Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas.
    4. Association between contactin 4 (CNTN4) and antisaccade and P300 in schizophrenia.
      Title: Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.
    5. SNPs within the CNTN4 gene are associated with increased risk of oral cancer.
      Title: Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer.
    6. SNPs in ITPR1 and CNTN4 are involved in the regulation of serum uric acid concentrations in Mexican Americans
      Title: GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.
    7. By combining methylation and SNP data, CNTN4 was identified as a risk factor for regular alcohol use.
      Title: Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.
    8. data reveal critical and novel roles for CNTN4/amyloid precursor protein in promoting target-specific axon arborization
      Title: Contactin-4 mediates axon-target specificity and functional development of the accessory optic system.
    9. We identified CNTN4 as a novel candidate gene for POAG.
      Title: Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins.
    10. these results suggest that rare copy number variations in CNTN4 may also influence autism susceptibility in Asian populations.
      Title: Disruption of Contactin 4 in two subjects with autism in Chinese population.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2022-06-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    No evidence available (Last evaluated 2022-06-14)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population.
    EBI GWAS Catalog
    A genome-wide association study of acenocoumarol maintenance dosage.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
    EBI GWAS Catalog
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.
    EBI GWAS Catalog
    Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
    EBI GWAS Catalog
    Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
    EBI GWAS Catalog
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
    EBI GWAS Catalog
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33615

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in axonal fasciculation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in axonogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synaptic plasticity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    contactin-4
    Names
    axonal-associated cell adhesion molecule
    brain-derived immunoglobulin superfamily protein 2
    neural cell adhesion protein BIG-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012827.2 RefSeqGene

      Range
      3304..962397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206955.2 → NP_001193884.1  contactin-4 isoform a precursor

      See identical proteins and their annotated locations for NP_001193884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 6 encode the same isoform (a).
      Source sequence(s)
      AC022002, AC024057, AF549455, R42166
      Consensus CDS
      CCDS43041.1
      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Related
      ENSP00000380602.1, ENST00000397461.5
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    2. NM_001206956.2 → NP_001193885.1  contactin-4 isoform d

      See identical proteins and their annotated locations for NP_001193885.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream in-frame start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC022002, BC026119, DB457029, R42166
      UniProtKB/TrEMBL
      B3KQ34
      Conserved Domains (2) summary
      cd00063
      Location:268 → 361
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:185 → 268
      Ig; Immunoglobulin domain

    3. NM_001350095.2 → NP_001337024.1  contactin-4 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 6 encode the same isoform (a).
      Source sequence(s)
      AC022002, AK125460, AY090737, BM718335, CD697898, CN282428, DN991363, R42166
      Consensus CDS
      CCDS43041.1
      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    4. NM_175607.3 → NP_783200.1  contactin-4 isoform a precursor

      See identical proteins and their annotated locations for NP_783200.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 4 and 6 encode the same isoform (a).
      Source sequence(s)
      AC022002, AF464063, AF549455, AY090737, DA063654, DA796385, R42166
      Consensus CDS
      CCDS43041.1
      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Related
      ENSP00000396010.1, ENST00000418658.6
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    5. NM_175613.3 → NP_783302.1  contactin-4 isoform c

      See identical proteins and their annotated locations for NP_783302.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC022002, AK314396, DB457029, R42166
      Consensus CDS
      CCDS2558.1
      UniProtKB/TrEMBL
      B3KQ34
      Related
      ENSP00000380600.2, ENST00000397459.6
      Conserved Domains (5) summary
      cd04969
      Location:94 → 166
      Ig5_Contactin_like; Fifth Ig domain of contactin
      cd05853
      Location:185 → 269
      Ig6_Contactin-4; Sixth Ig domain of contactin-4
      smart00410
      Location:87 → 166
      IG_like; Immunoglobulin like
      cd00063
      Location:269 → 362
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:4 → 73
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      2098866..3057959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005783.2 → XP_016861272.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    2. XM_047447536.1 → XP_047303492.1  contactin-4 isoform X2

    3. XM_011533427.3 → XP_011531729.1  contactin-4 isoform X1

      See identical proteins and their annotated locations for XP_011531729.1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    4. XM_017005785.2 → XP_016861274.1  contactin-4 isoform X2

      Conserved Domains (5) summary
      cd04969
      Location:422 → 494
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:415 → 494
      IG_like; Immunoglobulin like
      cd00063
      Location:596 → 689
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:26 → 117
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:513 → 596
      Ig; Immunoglobulin domain

    5. XM_017005782.2 → XP_016861271.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    6. XM_011533425.4 → XP_011531727.1  contactin-4 isoform X1

      See identical proteins and their annotated locations for XP_011531727.1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    7. XM_006713004.5 → XP_006713067.1  contactin-4 isoform X2

      Conserved Domains (5) summary
      cd04969
      Location:422 → 494
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:415 → 494
      IG_like; Immunoglobulin like
      cd00063
      Location:596 → 689
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:26 → 117
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:513 → 596
      Ig; Immunoglobulin domain

    8. XM_017005784.3 → XP_016861273.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    9. XM_047447535.1 → XP_047303491.1  contactin-4 isoform X2

    10. XM_047447518.1 → XP_047303474.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    11. XM_047447523.1 → XP_047303479.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    12. XM_047447528.1 → XP_047303484.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    13. XM_047447521.1 → XP_047303477.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    14. XM_047447520.1 → XP_047303476.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    15. XM_047447526.1 → XP_047303482.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    16. XM_047447525.1 → XP_047303481.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    17. XM_047447529.1 → XP_047303485.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    18. XM_047447522.1 → XP_047303478.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    19. XM_047447530.1 → XP_047303486.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    20. XM_047447532.1 → XP_047303488.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    21. XM_047447517.1 → XP_047303473.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    22. XM_047447524.1 → XP_047303480.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    23. XM_047447531.1 → XP_047303487.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    24. XM_047447533.1 → XP_047303489.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    25. XM_047447519.1 → XP_047303475.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    26. XM_047447527.1 → XP_047303483.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    27. XM_047447516.1 → XP_047303472.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    28. XM_047447534.1 → XP_047303490.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    29. XM_011533430.3 → XP_011531732.1  contactin-4 isoform X1

      See identical proteins and their annotated locations for XP_011531732.1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    30. XM_017005787.2 → XP_016861276.1  contactin-4 isoform X2

      Conserved Domains (5) summary
      cd04969
      Location:422 → 494
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:415 → 494
      IG_like; Immunoglobulin like
      cd00063
      Location:596 → 689
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:26 → 117
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:513 → 596
      Ig; Immunoglobulin domain

    31. XM_011533428.3 → XP_011531730.1  contactin-4 isoform X1

      See identical proteins and their annotated locations for XP_011531730.1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Related
      ENSP00000413642.1, ENST00000427331.5
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    32. XM_017005786.2 → XP_016861275.1  contactin-4 isoform X2

      Conserved Domains (5) summary
      cd04969
      Location:422 → 494
      Ig5_Contactin_like; Fifth Ig domain of contactin
      smart00410
      Location:415 → 494
      IG_like; Immunoglobulin like
      cd00063
      Location:596 → 689
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:26 → 117
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:513 → 596
      Ig; Immunoglobulin domain

    33. XM_011533429.3 → XP_011531731.1  contactin-4 isoform X1

      See identical proteins and their annotated locations for XP_011531731.1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35
      Conserved Domains (4) summary
      cd05853
      Location:513 → 597
      Ig6_Contactin-4; Sixth immunoglobulin (Ig) domain of contactin-4
      cd00063
      Location:597 → 690
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd04969
      Location:422 → 494
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:225 → 313
      Ig; Immunoglobulin domain

    34. XM_011533431.3 → XP_011531733.1  contactin-4 isoform X3

      Conserved Domains (6) summary
      cd04969
      Location:411 → 483
      Ig5_Contactin_like; Fifth Ig domain of contactin
      cd05853
      Location:502 → 586
      Ig6_Contactin-4; Sixth Ig domain of contactin-4
      smart00410
      Location:404 → 483
      IG_like; Immunoglobulin like
      cd00063
      Location:586 → 679
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:15 → 106
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:214 → 302
      Ig; Immunoglobulin domain

    35. XM_047447537.1 → XP_047303493.1  contactin-4 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      2092772..3052283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345401.1 → XP_054201376.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    2. XM_054345417.1 → XP_054201392.1  contactin-4 isoform X2

    3. XM_054345402.1 → XP_054201377.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    4. XM_054345416.1 → XP_054201391.1  contactin-4 isoform X2

    5. XM_054345400.1 → XP_054201375.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    6. XM_054345399.1 → XP_054201374.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    7. XM_054345420.1 → XP_054201395.1  contactin-4 isoform X2

    8. XM_054345406.1 → XP_054201381.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    9. XM_054345410.1 → XP_054201385.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    10. XM_054345412.1 → XP_054201387.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    11. XM_054345413.1 → XP_054201388.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    12. XM_054345407.1 → XP_054201382.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    13. XM_054345409.1 → XP_054201384.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    14. XM_054345408.1 → XP_054201383.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    15. XM_054345411.1 → XP_054201386.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    16. XM_054345405.1 → XP_054201380.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    17. XM_054345414.1 → XP_054201389.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    18. XM_054345423.1 → XP_054201398.1  contactin-4 isoform X5

    19. XM_054345404.1 → XP_054201379.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    20. XM_054345419.1 → XP_054201394.1  contactin-4 isoform X2

    21. XM_054345403.1 → XP_054201378.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    22. XM_054345418.1 → XP_054201393.1  contactin-4 isoform X2

    23. XM_054345415.1 → XP_054201390.1  contactin-4 isoform X1

      UniProtKB/Swiss-Prot
      B2RAX3, Q8IWV2, Q8IX14, Q8TC35

    24. XM_054345421.1 → XP_054201396.1  contactin-4 isoform X3

    25. XM_054345422.1 → XP_054201397.1  contactin-4 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175612.1: Suppressed sequence

      Description
      NM_175612.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWV2.1 GenPept UniProtKB/Swiss-Prot:Q8IWV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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